Cargando…
Successful Treatment of Primary Cutaneous Anaplastic Large Cell Lymphoma with Denileukin Diftitox
Primary cutaneous anaplastic large cell lymphoma (PCALCL) is a rare variant of cutaneous T cell lymphoma (CTCL) characterized by CD30-expressing large atypical cells with kidney-shaped nuclei called hallmark cells. Since PCALCL is a rare variant of CTCL, the treatment of PCALCL is still controversia...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9459557/ https://www.ncbi.nlm.nih.gov/pubmed/36157690 http://dx.doi.org/10.1159/000526312 |
_version_ | 1784786539182555136 |
---|---|
author | Amagai, Mayuko Furudate, Sadanori Ohuchi, Kentaro Takahashi, Toshiya Yamazaki, Emi Chiba, Hiromu Asano, Yoshihide Fujimura, Taku |
author_facet | Amagai, Mayuko Furudate, Sadanori Ohuchi, Kentaro Takahashi, Toshiya Yamazaki, Emi Chiba, Hiromu Asano, Yoshihide Fujimura, Taku |
author_sort | Amagai, Mayuko |
collection | PubMed |
description | Primary cutaneous anaplastic large cell lymphoma (PCALCL) is a rare variant of cutaneous T cell lymphoma (CTCL) characterized by CD30-expressing large atypical cells with kidney-shaped nuclei called hallmark cells. Since PCALCL is a rare variant of CTCL, the treatment of PCALCL is still controversial. In this report, a case of PCALCL successfully treated with denileukin diftitox as second-line therapy is described. Interestingly, the administration of denileukin diftitox decreased CD8+ T cells, CD25+ cells, granulysin-bearing lymphocytes, and CD163+ macrophages. The present case suggests that denileukin diftitox might induce an anti-lymphoma effect as well as modulate the tumor microenvironment. |
format | Online Article Text |
id | pubmed-9459557 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-94595572022-09-23 Successful Treatment of Primary Cutaneous Anaplastic Large Cell Lymphoma with Denileukin Diftitox Amagai, Mayuko Furudate, Sadanori Ohuchi, Kentaro Takahashi, Toshiya Yamazaki, Emi Chiba, Hiromu Asano, Yoshihide Fujimura, Taku Case Rep Oncol Case Report Primary cutaneous anaplastic large cell lymphoma (PCALCL) is a rare variant of cutaneous T cell lymphoma (CTCL) characterized by CD30-expressing large atypical cells with kidney-shaped nuclei called hallmark cells. Since PCALCL is a rare variant of CTCL, the treatment of PCALCL is still controversial. In this report, a case of PCALCL successfully treated with denileukin diftitox as second-line therapy is described. Interestingly, the administration of denileukin diftitox decreased CD8+ T cells, CD25+ cells, granulysin-bearing lymphocytes, and CD163+ macrophages. The present case suggests that denileukin diftitox might induce an anti-lymphoma effect as well as modulate the tumor microenvironment. S. Karger AG 2022-08-26 /pmc/articles/PMC9459557/ /pubmed/36157690 http://dx.doi.org/10.1159/000526312 Text en Copyright © 2022 by The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission. |
spellingShingle | Case Report Amagai, Mayuko Furudate, Sadanori Ohuchi, Kentaro Takahashi, Toshiya Yamazaki, Emi Chiba, Hiromu Asano, Yoshihide Fujimura, Taku Successful Treatment of Primary Cutaneous Anaplastic Large Cell Lymphoma with Denileukin Diftitox |
title | Successful Treatment of Primary Cutaneous Anaplastic Large Cell Lymphoma with Denileukin Diftitox |
title_full | Successful Treatment of Primary Cutaneous Anaplastic Large Cell Lymphoma with Denileukin Diftitox |
title_fullStr | Successful Treatment of Primary Cutaneous Anaplastic Large Cell Lymphoma with Denileukin Diftitox |
title_full_unstemmed | Successful Treatment of Primary Cutaneous Anaplastic Large Cell Lymphoma with Denileukin Diftitox |
title_short | Successful Treatment of Primary Cutaneous Anaplastic Large Cell Lymphoma with Denileukin Diftitox |
title_sort | successful treatment of primary cutaneous anaplastic large cell lymphoma with denileukin diftitox |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9459557/ https://www.ncbi.nlm.nih.gov/pubmed/36157690 http://dx.doi.org/10.1159/000526312 |
work_keys_str_mv | AT amagaimayuko successfultreatmentofprimarycutaneousanaplasticlargecelllymphomawithdenileukindiftitox AT furudatesadanori successfultreatmentofprimarycutaneousanaplasticlargecelllymphomawithdenileukindiftitox AT ohuchikentaro successfultreatmentofprimarycutaneousanaplasticlargecelllymphomawithdenileukindiftitox AT takahashitoshiya successfultreatmentofprimarycutaneousanaplasticlargecelllymphomawithdenileukindiftitox AT yamazakiemi successfultreatmentofprimarycutaneousanaplasticlargecelllymphomawithdenileukindiftitox AT chibahiromu successfultreatmentofprimarycutaneousanaplasticlargecelllymphomawithdenileukindiftitox AT asanoyoshihide successfultreatmentofprimarycutaneousanaplasticlargecelllymphomawithdenileukindiftitox AT fujimurataku successfultreatmentofprimarycutaneousanaplasticlargecelllymphomawithdenileukindiftitox |