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Successful Treatment of Primary Cutaneous Anaplastic Large Cell Lymphoma with Denileukin Diftitox

Primary cutaneous anaplastic large cell lymphoma (PCALCL) is a rare variant of cutaneous T cell lymphoma (CTCL) characterized by CD30-expressing large atypical cells with kidney-shaped nuclei called hallmark cells. Since PCALCL is a rare variant of CTCL, the treatment of PCALCL is still controversia...

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Autores principales: Amagai, Mayuko, Furudate, Sadanori, Ohuchi, Kentaro, Takahashi, Toshiya, Yamazaki, Emi, Chiba, Hiromu, Asano, Yoshihide, Fujimura, Taku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9459557/
https://www.ncbi.nlm.nih.gov/pubmed/36157690
http://dx.doi.org/10.1159/000526312
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author Amagai, Mayuko
Furudate, Sadanori
Ohuchi, Kentaro
Takahashi, Toshiya
Yamazaki, Emi
Chiba, Hiromu
Asano, Yoshihide
Fujimura, Taku
author_facet Amagai, Mayuko
Furudate, Sadanori
Ohuchi, Kentaro
Takahashi, Toshiya
Yamazaki, Emi
Chiba, Hiromu
Asano, Yoshihide
Fujimura, Taku
author_sort Amagai, Mayuko
collection PubMed
description Primary cutaneous anaplastic large cell lymphoma (PCALCL) is a rare variant of cutaneous T cell lymphoma (CTCL) characterized by CD30-expressing large atypical cells with kidney-shaped nuclei called hallmark cells. Since PCALCL is a rare variant of CTCL, the treatment of PCALCL is still controversial. In this report, a case of PCALCL successfully treated with denileukin diftitox as second-line therapy is described. Interestingly, the administration of denileukin diftitox decreased CD8+ T cells, CD25+ cells, granulysin-bearing lymphocytes, and CD163+ macrophages. The present case suggests that denileukin diftitox might induce an anti-lymphoma effect as well as modulate the tumor microenvironment.
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spelling pubmed-94595572022-09-23 Successful Treatment of Primary Cutaneous Anaplastic Large Cell Lymphoma with Denileukin Diftitox Amagai, Mayuko Furudate, Sadanori Ohuchi, Kentaro Takahashi, Toshiya Yamazaki, Emi Chiba, Hiromu Asano, Yoshihide Fujimura, Taku Case Rep Oncol Case Report Primary cutaneous anaplastic large cell lymphoma (PCALCL) is a rare variant of cutaneous T cell lymphoma (CTCL) characterized by CD30-expressing large atypical cells with kidney-shaped nuclei called hallmark cells. Since PCALCL is a rare variant of CTCL, the treatment of PCALCL is still controversial. In this report, a case of PCALCL successfully treated with denileukin diftitox as second-line therapy is described. Interestingly, the administration of denileukin diftitox decreased CD8+ T cells, CD25+ cells, granulysin-bearing lymphocytes, and CD163+ macrophages. The present case suggests that denileukin diftitox might induce an anti-lymphoma effect as well as modulate the tumor microenvironment. S. Karger AG 2022-08-26 /pmc/articles/PMC9459557/ /pubmed/36157690 http://dx.doi.org/10.1159/000526312 Text en Copyright © 2022 by The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Amagai, Mayuko
Furudate, Sadanori
Ohuchi, Kentaro
Takahashi, Toshiya
Yamazaki, Emi
Chiba, Hiromu
Asano, Yoshihide
Fujimura, Taku
Successful Treatment of Primary Cutaneous Anaplastic Large Cell Lymphoma with Denileukin Diftitox
title Successful Treatment of Primary Cutaneous Anaplastic Large Cell Lymphoma with Denileukin Diftitox
title_full Successful Treatment of Primary Cutaneous Anaplastic Large Cell Lymphoma with Denileukin Diftitox
title_fullStr Successful Treatment of Primary Cutaneous Anaplastic Large Cell Lymphoma with Denileukin Diftitox
title_full_unstemmed Successful Treatment of Primary Cutaneous Anaplastic Large Cell Lymphoma with Denileukin Diftitox
title_short Successful Treatment of Primary Cutaneous Anaplastic Large Cell Lymphoma with Denileukin Diftitox
title_sort successful treatment of primary cutaneous anaplastic large cell lymphoma with denileukin diftitox
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9459557/
https://www.ncbi.nlm.nih.gov/pubmed/36157690
http://dx.doi.org/10.1159/000526312
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