Sotorasib Shows Intracranial Activity in Patients with KRAS G12C-Mutated Adenocarcinoma of the Lung and Untreated Active Brain Metastases

Treatment with sotorasib has shown intracranial complete responses and continued intracranial stabilization in KRAS G12C-mutated non-small-cell lung carcinoma (NSCLC) patients with previously treated, stable brain metastases in a post hoc analysis of the ongoing CodeBreaK 100 trial. We present the c...

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Detalles Bibliográficos
Autores principales: Koster, Kira-Lee, Appenzeller, Christina, Lauber, Arno, Früh, Martin, Schmid, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9459558/
https://www.ncbi.nlm.nih.gov/pubmed/36157699
http://dx.doi.org/10.1159/000525341
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author Koster, Kira-Lee
Appenzeller, Christina
Lauber, Arno
Früh, Martin
Schmid, Sabine
author_facet Koster, Kira-Lee
Appenzeller, Christina
Lauber, Arno
Früh, Martin
Schmid, Sabine
author_sort Koster, Kira-Lee
collection PubMed
description Treatment with sotorasib has shown intracranial complete responses and continued intracranial stabilization in KRAS G12C-mutated non-small-cell lung carcinoma (NSCLC) patients with previously treated, stable brain metastases in a post hoc analysis of the ongoing CodeBreaK 100 trial. We present the case of a patient with KRAS G12C-mutant adenocarcinoma of the lung with active untreated brain metastases with a nearly complete intracranial response only 6 weeks after start of sotorasib illustrating the benefit of sotorasib in patients with active, previously untreated brain metastases in KRAS G12C-mutated NSCLC.
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spelling pubmed-94595582022-09-23 Sotorasib Shows Intracranial Activity in Patients with KRAS G12C-Mutated Adenocarcinoma of the Lung and Untreated Active Brain Metastases Koster, Kira-Lee Appenzeller, Christina Lauber, Arno Früh, Martin Schmid, Sabine Case Rep Oncol Case Report Treatment with sotorasib has shown intracranial complete responses and continued intracranial stabilization in KRAS G12C-mutated non-small-cell lung carcinoma (NSCLC) patients with previously treated, stable brain metastases in a post hoc analysis of the ongoing CodeBreaK 100 trial. We present the case of a patient with KRAS G12C-mutant adenocarcinoma of the lung with active untreated brain metastases with a nearly complete intracranial response only 6 weeks after start of sotorasib illustrating the benefit of sotorasib in patients with active, previously untreated brain metastases in KRAS G12C-mutated NSCLC. S. Karger AG 2022-08-26 /pmc/articles/PMC9459558/ /pubmed/36157699 http://dx.doi.org/10.1159/000525341 Text en Copyright © 2022 by The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Koster, Kira-Lee
Appenzeller, Christina
Lauber, Arno
Früh, Martin
Schmid, Sabine
Sotorasib Shows Intracranial Activity in Patients with KRAS G12C-Mutated Adenocarcinoma of the Lung and Untreated Active Brain Metastases
title Sotorasib Shows Intracranial Activity in Patients with KRAS G12C-Mutated Adenocarcinoma of the Lung and Untreated Active Brain Metastases
title_full Sotorasib Shows Intracranial Activity in Patients with KRAS G12C-Mutated Adenocarcinoma of the Lung and Untreated Active Brain Metastases
title_fullStr Sotorasib Shows Intracranial Activity in Patients with KRAS G12C-Mutated Adenocarcinoma of the Lung and Untreated Active Brain Metastases
title_full_unstemmed Sotorasib Shows Intracranial Activity in Patients with KRAS G12C-Mutated Adenocarcinoma of the Lung and Untreated Active Brain Metastases
title_short Sotorasib Shows Intracranial Activity in Patients with KRAS G12C-Mutated Adenocarcinoma of the Lung and Untreated Active Brain Metastases
title_sort sotorasib shows intracranial activity in patients with kras g12c-mutated adenocarcinoma of the lung and untreated active brain metastases
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9459558/
https://www.ncbi.nlm.nih.gov/pubmed/36157699
http://dx.doi.org/10.1159/000525341
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