Blue Skin, Nail, and Scleral Pigmentation Associated with Minocycline

Minocycline, a semisynthetic derivative of tetracycline that is used to treat various infectious and noninfectious conditions, can cause tissue hyperpigmentation. The skin, oral mucosa, sclera, and rarely the nails, can all be affected. The discoloration varies from blue, slate-gray, or brown, and i...

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Autores principales: Ricardo, Jose W., Shah, Kalee, Minkis, Kira, Lipner, Shari R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2022
Materias:
Single Case
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9459581/
https://www.ncbi.nlm.nih.gov/pubmed/36158857
http://dx.doi.org/10.1159/000526067
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author Ricardo, Jose W.
Shah, Kalee
Minkis, Kira
Lipner, Shari R.
author_facet Ricardo, Jose W.
Shah, Kalee
Minkis, Kira
Lipner, Shari R.
author_sort Ricardo, Jose W.
collection PubMed
description Minocycline, a semisynthetic derivative of tetracycline that is used to treat various infectious and noninfectious conditions, can cause tissue hyperpigmentation. The skin, oral mucosa, sclera, and rarely the nails, can all be affected. The discoloration varies from blue, slate-gray, or brown, and it typically occurs in a dose-dependent fashion. The mechanism of hyperpigmentation, however, remains largely unknown. Herein, we present a case of gray-blue hyperpigmentation of the skin, sclera, and nails after long-term treatment with minocycline for acne.
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spelling pubmed-94595812022-09-23 Blue Skin, Nail, and Scleral Pigmentation Associated with Minocycline Ricardo, Jose W. Shah, Kalee Minkis, Kira Lipner, Shari R. Case Rep Dermatol Single Case Minocycline, a semisynthetic derivative of tetracycline that is used to treat various infectious and noninfectious conditions, can cause tissue hyperpigmentation. The skin, oral mucosa, sclera, and rarely the nails, can all be affected. The discoloration varies from blue, slate-gray, or brown, and it typically occurs in a dose-dependent fashion. The mechanism of hyperpigmentation, however, remains largely unknown. Herein, we present a case of gray-blue hyperpigmentation of the skin, sclera, and nails after long-term treatment with minocycline for acne. S. Karger AG 2022-08-19 /pmc/articles/PMC9459581/ /pubmed/36158857 http://dx.doi.org/10.1159/000526067 Text en Copyright © 2022 by The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Single Case
Ricardo, Jose W.
Shah, Kalee
Minkis, Kira
Lipner, Shari R.
Blue Skin, Nail, and Scleral Pigmentation Associated with Minocycline
title Blue Skin, Nail, and Scleral Pigmentation Associated with Minocycline
title_full Blue Skin, Nail, and Scleral Pigmentation Associated with Minocycline
title_fullStr Blue Skin, Nail, and Scleral Pigmentation Associated with Minocycline
title_full_unstemmed Blue Skin, Nail, and Scleral Pigmentation Associated with Minocycline
title_short Blue Skin, Nail, and Scleral Pigmentation Associated with Minocycline
title_sort blue skin, nail, and scleral pigmentation associated with minocycline
topic Single Case
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9459581/
https://www.ncbi.nlm.nih.gov/pubmed/36158857
http://dx.doi.org/10.1159/000526067
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