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Bilateral Panuveitis and Exudative Retinal Detachments Associated with Alpelisib
We report a case of alpelisib-induced uveitis. A 68-year-old female who had recently been given alpelisib for metastatic breast cancer presented with a 2-week history of bilateral worsening vision with a corresponding acute hypermetropic shift. Her unaided visual acuity was 6/60 in both eyes, with b...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9459638/ https://www.ncbi.nlm.nih.gov/pubmed/36157688 http://dx.doi.org/10.1159/000525772 |
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author | Chong, Yu Jeat Azzopardi, Matthew Tallouzi, Mohammad Omar Spooner, David Masood, Imran Ghosh, Yajati Sreekantam, Sreekanth |
author_facet | Chong, Yu Jeat Azzopardi, Matthew Tallouzi, Mohammad Omar Spooner, David Masood, Imran Ghosh, Yajati Sreekantam, Sreekanth |
author_sort | Chong, Yu Jeat |
collection | PubMed |
description | We report a case of alpelisib-induced uveitis. A 68-year-old female who had recently been given alpelisib for metastatic breast cancer presented with a 2-week history of bilateral worsening vision with a corresponding acute hypermetropic shift. Her unaided visual acuity was 6/60 in both eyes, with bilateral anterior uveitis, non-granulomatous keratic precipitates, posterior synechiae, and limited fundal view. There was also a mild iris bombe configuration, although the intraocular pressures were normal. Ocular ultrasound revealed bilateral uveal effusion, ciliary body congestion, dense vitreous cells, and exudative retinal detachments. These findings were also confirmed on multimodal imaging with widefield fundus photography (Optos) and optical coherence tomography. Based on the clinical features above, a diagnosis of alpelisib-induced panuveitis was diagnosed. She was then admitted and treated with a 3-day course of intravenous methylprednisolone and intensive topical steroids. Her clinical signs and symptoms started to improve, and she was discharged 4 days later. At 1 week of follow-up, her best-corrected visual acuity was 6/12 in both eyes, with broken posterior synechiae and resolution of exudative retinal detachments. This case highlights the importance of early ophthalmology involvement by the oncology team as oncology therapy can have potential unexpected ocular manifestations. |
format | Online Article Text |
id | pubmed-9459638 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-94596382022-09-23 Bilateral Panuveitis and Exudative Retinal Detachments Associated with Alpelisib Chong, Yu Jeat Azzopardi, Matthew Tallouzi, Mohammad Omar Spooner, David Masood, Imran Ghosh, Yajati Sreekantam, Sreekanth Case Rep Oncol Case Report We report a case of alpelisib-induced uveitis. A 68-year-old female who had recently been given alpelisib for metastatic breast cancer presented with a 2-week history of bilateral worsening vision with a corresponding acute hypermetropic shift. Her unaided visual acuity was 6/60 in both eyes, with bilateral anterior uveitis, non-granulomatous keratic precipitates, posterior synechiae, and limited fundal view. There was also a mild iris bombe configuration, although the intraocular pressures were normal. Ocular ultrasound revealed bilateral uveal effusion, ciliary body congestion, dense vitreous cells, and exudative retinal detachments. These findings were also confirmed on multimodal imaging with widefield fundus photography (Optos) and optical coherence tomography. Based on the clinical features above, a diagnosis of alpelisib-induced panuveitis was diagnosed. She was then admitted and treated with a 3-day course of intravenous methylprednisolone and intensive topical steroids. Her clinical signs and symptoms started to improve, and she was discharged 4 days later. At 1 week of follow-up, her best-corrected visual acuity was 6/12 in both eyes, with broken posterior synechiae and resolution of exudative retinal detachments. This case highlights the importance of early ophthalmology involvement by the oncology team as oncology therapy can have potential unexpected ocular manifestations. S. Karger AG 2022-08-03 /pmc/articles/PMC9459638/ /pubmed/36157688 http://dx.doi.org/10.1159/000525772 Text en Copyright © 2022 by The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission. |
spellingShingle | Case Report Chong, Yu Jeat Azzopardi, Matthew Tallouzi, Mohammad Omar Spooner, David Masood, Imran Ghosh, Yajati Sreekantam, Sreekanth Bilateral Panuveitis and Exudative Retinal Detachments Associated with Alpelisib |
title | Bilateral Panuveitis and Exudative Retinal Detachments Associated with Alpelisib |
title_full | Bilateral Panuveitis and Exudative Retinal Detachments Associated with Alpelisib |
title_fullStr | Bilateral Panuveitis and Exudative Retinal Detachments Associated with Alpelisib |
title_full_unstemmed | Bilateral Panuveitis and Exudative Retinal Detachments Associated with Alpelisib |
title_short | Bilateral Panuveitis and Exudative Retinal Detachments Associated with Alpelisib |
title_sort | bilateral panuveitis and exudative retinal detachments associated with alpelisib |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9459638/ https://www.ncbi.nlm.nih.gov/pubmed/36157688 http://dx.doi.org/10.1159/000525772 |
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