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Magnetization transfer imaging of ovarian cancer: initial experiences of correlation with tissue cellularity and changes following neoadjuvant chemotherapy
OBJECTIVES: To investigate the relationship between magnetization transfer (MT) imaging and tissue macromolecules in high-grade serous ovarian cancer (HGSOC) and whether MT ratio (MTR) changes following neoadjuvant chemotherapy (NACT). METHODS: This was a prospective observational study. 12 HGSOC pa...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The British Institute of Radiology.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9459873/ https://www.ncbi.nlm.nih.gov/pubmed/36105417 http://dx.doi.org/10.1259/bjro.20210078 |
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author | Deen, Surrin S McLean, Mary A Gill, Andrew B Crawford, Robin A F Latimer, John Baldwin, Peter Earl, Helena M Parkinson, Christine A Smith, Sarah Hodgkin, Charlotte Jimenez-Linan, Mercedes Brodie, Cara R Patterson, Ilse Addley, Helen C Freeman, Susan J Moyle, Penelope M Graves, Martin J Sala, Evis Brenton, James D Gallagher, Ferdia A |
author_facet | Deen, Surrin S McLean, Mary A Gill, Andrew B Crawford, Robin A F Latimer, John Baldwin, Peter Earl, Helena M Parkinson, Christine A Smith, Sarah Hodgkin, Charlotte Jimenez-Linan, Mercedes Brodie, Cara R Patterson, Ilse Addley, Helen C Freeman, Susan J Moyle, Penelope M Graves, Martin J Sala, Evis Brenton, James D Gallagher, Ferdia A |
author_sort | Deen, Surrin S |
collection | PubMed |
description | OBJECTIVES: To investigate the relationship between magnetization transfer (MT) imaging and tissue macromolecules in high-grade serous ovarian cancer (HGSOC) and whether MT ratio (MTR) changes following neoadjuvant chemotherapy (NACT). METHODS: This was a prospective observational study. 12 HGSOC patients were imaged before treatment. MTR was compared to quantified tissue histology and immunohistochemistry. For a subset of patients (n = 5), MT imaging was repeated after NACT. The Shapiro–Wilk test was used to assess for normality of data and Spearman’s rank-order or Pearson’s correlation tests were then used to compare MTR with tissue quantifications. The Wilcoxon signed-rank test was used to assess for changes in MTR after treatment. RESULTS: Treatment-naïve tumour MTR was 21.9 ± 3.1% (mean ± S.D.). MTR had a positive correlation with cellularity, rho = 0.56 (p < 0.05) and a negative correlation with tumour volume, ρ = −0.72 (p = 0.01). MTR did not correlate with the extracellular proteins, collagen IV or laminin (p = 0.40 and p = 0.90). For those patients imaged before and after NACT, an increase in MTR was observed in each case with mean MTR 20.6 ± 3.1% (median 21.1) pre-treatment and 25.6 ± 3.4% (median 26.5) post-treatment (p = 0.06). CONCLUSION: In treatment-naïve HGSOC, MTR is associated with cellularity, possibly reflecting intracellular macromolecular concentration. MT may also detect the HGSOC response to NACT, however larger studies are required to validate this finding. ADVANCES IN KNOWLEDGE: MTR in HGSOC is influenced by cellularity. This may be applied to assess for cell changes following treatment. |
format | Online Article Text |
id | pubmed-9459873 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The British Institute of Radiology. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94598732022-09-13 Magnetization transfer imaging of ovarian cancer: initial experiences of correlation with tissue cellularity and changes following neoadjuvant chemotherapy Deen, Surrin S McLean, Mary A Gill, Andrew B Crawford, Robin A F Latimer, John Baldwin, Peter Earl, Helena M Parkinson, Christine A Smith, Sarah Hodgkin, Charlotte Jimenez-Linan, Mercedes Brodie, Cara R Patterson, Ilse Addley, Helen C Freeman, Susan J Moyle, Penelope M Graves, Martin J Sala, Evis Brenton, James D Gallagher, Ferdia A BJR Open Original Research OBJECTIVES: To investigate the relationship between magnetization transfer (MT) imaging and tissue macromolecules in high-grade serous ovarian cancer (HGSOC) and whether MT ratio (MTR) changes following neoadjuvant chemotherapy (NACT). METHODS: This was a prospective observational study. 12 HGSOC patients were imaged before treatment. MTR was compared to quantified tissue histology and immunohistochemistry. For a subset of patients (n = 5), MT imaging was repeated after NACT. The Shapiro–Wilk test was used to assess for normality of data and Spearman’s rank-order or Pearson’s correlation tests were then used to compare MTR with tissue quantifications. The Wilcoxon signed-rank test was used to assess for changes in MTR after treatment. RESULTS: Treatment-naïve tumour MTR was 21.9 ± 3.1% (mean ± S.D.). MTR had a positive correlation with cellularity, rho = 0.56 (p < 0.05) and a negative correlation with tumour volume, ρ = −0.72 (p = 0.01). MTR did not correlate with the extracellular proteins, collagen IV or laminin (p = 0.40 and p = 0.90). For those patients imaged before and after NACT, an increase in MTR was observed in each case with mean MTR 20.6 ± 3.1% (median 21.1) pre-treatment and 25.6 ± 3.4% (median 26.5) post-treatment (p = 0.06). CONCLUSION: In treatment-naïve HGSOC, MTR is associated with cellularity, possibly reflecting intracellular macromolecular concentration. MT may also detect the HGSOC response to NACT, however larger studies are required to validate this finding. ADVANCES IN KNOWLEDGE: MTR in HGSOC is influenced by cellularity. This may be applied to assess for cell changes following treatment. The British Institute of Radiology. 2022-05-02 /pmc/articles/PMC9459873/ /pubmed/36105417 http://dx.doi.org/10.1259/bjro.20210078 Text en © 2022 The Authors. Published by the British Institute of Radiology https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Original Research Deen, Surrin S McLean, Mary A Gill, Andrew B Crawford, Robin A F Latimer, John Baldwin, Peter Earl, Helena M Parkinson, Christine A Smith, Sarah Hodgkin, Charlotte Jimenez-Linan, Mercedes Brodie, Cara R Patterson, Ilse Addley, Helen C Freeman, Susan J Moyle, Penelope M Graves, Martin J Sala, Evis Brenton, James D Gallagher, Ferdia A Magnetization transfer imaging of ovarian cancer: initial experiences of correlation with tissue cellularity and changes following neoadjuvant chemotherapy |
title | Magnetization transfer imaging of ovarian cancer: initial experiences of correlation with tissue cellularity and changes following neoadjuvant chemotherapy |
title_full | Magnetization transfer imaging of ovarian cancer: initial experiences of correlation with tissue cellularity and changes following neoadjuvant chemotherapy |
title_fullStr | Magnetization transfer imaging of ovarian cancer: initial experiences of correlation with tissue cellularity and changes following neoadjuvant chemotherapy |
title_full_unstemmed | Magnetization transfer imaging of ovarian cancer: initial experiences of correlation with tissue cellularity and changes following neoadjuvant chemotherapy |
title_short | Magnetization transfer imaging of ovarian cancer: initial experiences of correlation with tissue cellularity and changes following neoadjuvant chemotherapy |
title_sort | magnetization transfer imaging of ovarian cancer: initial experiences of correlation with tissue cellularity and changes following neoadjuvant chemotherapy |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9459873/ https://www.ncbi.nlm.nih.gov/pubmed/36105417 http://dx.doi.org/10.1259/bjro.20210078 |
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