Synthesis and Activity of Ionic Antioxidant-Functionalized PAMAMs and PPIs Dendrimers

For this study, new dendrimers were prepared from poly(propylene imine) (PPI) and polyamidoamine (PAMAM) dendrimers using an efficient acid-base reaction with various phenolic acids. The syntheses were also optimized in both microwave and microfluidic reactors. These ionic and hydrophilic dendrimers...

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Detalles Bibliográficos
Autores principales: Bacha, Katia, Estager, Julien, Brassart-Pasco, Sylvie, Chemotti, Catherine, Fernandes, Antony E., Mbakidi, Jean-Pierre, Deleu, Magali, Bouquillon, Sandrine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9459880/
https://www.ncbi.nlm.nih.gov/pubmed/36080588
http://dx.doi.org/10.3390/polym14173513
Descripción
Sumario:For this study, new dendrimers were prepared from poly(propylene imine) (PPI) and polyamidoamine (PAMAM) dendrimers using an efficient acid-base reaction with various phenolic acids. The syntheses were also optimized in both microwave and microfluidic reactors. These ionic and hydrophilic dendrimers were fully characterized and showed excellent antioxidant properties. Their cytotoxic properties have been also determined in the case of fibroblast dermal cells.

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