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Hyaluronic Acid: A Review of the Drug Delivery Capabilities of This Naturally Occurring Polysaccharide

The inclusion of physiologically active molecules into a naturally occurring polymer matrix can improve the degradation, absorption, and release profile of the drug, thus boosting the therapeutic impact and potentially even reducing the frequency of administration. The human body produces significan...

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Detalles Bibliográficos
Autores principales: Buckley, Ciara, Murphy, Emma J., Montgomery, Therese R., Major, Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9460006/
https://www.ncbi.nlm.nih.gov/pubmed/36080515
http://dx.doi.org/10.3390/polym14173442
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author Buckley, Ciara
Murphy, Emma J.
Montgomery, Therese R.
Major, Ian
author_facet Buckley, Ciara
Murphy, Emma J.
Montgomery, Therese R.
Major, Ian
author_sort Buckley, Ciara
collection PubMed
description The inclusion of physiologically active molecules into a naturally occurring polymer matrix can improve the degradation, absorption, and release profile of the drug, thus boosting the therapeutic impact and potentially even reducing the frequency of administration. The human body produces significant amounts of polysaccharide hyaluronic acid, which boasts exceptional biocompatibility, biodegradability, and one-of-a-kind physicochemical features. In this review, we will examine the clinical trials currently utilizing hyaluronic acid and address the bright future of this versatile polymer, as well as summarize the numerous applications of hyaluronic acid in drug delivery and immunomodulation.
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spelling pubmed-94600062022-09-10 Hyaluronic Acid: A Review of the Drug Delivery Capabilities of This Naturally Occurring Polysaccharide Buckley, Ciara Murphy, Emma J. Montgomery, Therese R. Major, Ian Polymers (Basel) Review The inclusion of physiologically active molecules into a naturally occurring polymer matrix can improve the degradation, absorption, and release profile of the drug, thus boosting the therapeutic impact and potentially even reducing the frequency of administration. The human body produces significant amounts of polysaccharide hyaluronic acid, which boasts exceptional biocompatibility, biodegradability, and one-of-a-kind physicochemical features. In this review, we will examine the clinical trials currently utilizing hyaluronic acid and address the bright future of this versatile polymer, as well as summarize the numerous applications of hyaluronic acid in drug delivery and immunomodulation. MDPI 2022-08-23 /pmc/articles/PMC9460006/ /pubmed/36080515 http://dx.doi.org/10.3390/polym14173442 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Buckley, Ciara
Murphy, Emma J.
Montgomery, Therese R.
Major, Ian
Hyaluronic Acid: A Review of the Drug Delivery Capabilities of This Naturally Occurring Polysaccharide
title Hyaluronic Acid: A Review of the Drug Delivery Capabilities of This Naturally Occurring Polysaccharide
title_full Hyaluronic Acid: A Review of the Drug Delivery Capabilities of This Naturally Occurring Polysaccharide
title_fullStr Hyaluronic Acid: A Review of the Drug Delivery Capabilities of This Naturally Occurring Polysaccharide
title_full_unstemmed Hyaluronic Acid: A Review of the Drug Delivery Capabilities of This Naturally Occurring Polysaccharide
title_short Hyaluronic Acid: A Review of the Drug Delivery Capabilities of This Naturally Occurring Polysaccharide
title_sort hyaluronic acid: a review of the drug delivery capabilities of this naturally occurring polysaccharide
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9460006/
https://www.ncbi.nlm.nih.gov/pubmed/36080515
http://dx.doi.org/10.3390/polym14173442
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