Successful case of olaparib treatment for castration-resistant prostate cancer with multiple DNA repair gene mutations: Use of comprehensive genome profiling for treatment-refractory cases

Herein, we report a case of a 59-year-old man with advanced castration-resistant prostate cancer with rectal invasion. Multimodal treatment, including drug therapy, surgery, and radiation therapy was sequentially performed; however, lymph node metastases repeatedly occurred. Tumor genomic profiling...

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Detalles Bibliográficos
Autores principales: Hirayama, Yukiyoshi, Kato, Minoru, Kimura, Kaoru, Otoshi, Taiyo, Yamasaki, Takeshi, Uchida, Junji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9460157/
https://www.ncbi.nlm.nih.gov/pubmed/36092022
http://dx.doi.org/10.1016/j.eucr.2022.102210
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author Hirayama, Yukiyoshi
Kato, Minoru
Kimura, Kaoru
Otoshi, Taiyo
Yamasaki, Takeshi
Uchida, Junji
author_facet Hirayama, Yukiyoshi
Kato, Minoru
Kimura, Kaoru
Otoshi, Taiyo
Yamasaki, Takeshi
Uchida, Junji
author_sort Hirayama, Yukiyoshi
collection PubMed
description Herein, we report a case of a 59-year-old man with advanced castration-resistant prostate cancer with rectal invasion. Multimodal treatment, including drug therapy, surgery, and radiation therapy was sequentially performed; however, lymph node metastases repeatedly occurred. Tumor genomic profiling using FoundationOne CDx identified pathogenic alterations in three DNA repair genes, including BRCA2 frameshift mutation. Olaparib, a poly-ADP ribose polymerase inhibitor, showed marked response. Castration-resistant prostate cancer with multiple DNA repair genes was successfully treated with olaparib; comprehensive genome profiling can lead to its optimal clinical management.
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spelling pubmed-94601572022-09-10 Successful case of olaparib treatment for castration-resistant prostate cancer with multiple DNA repair gene mutations: Use of comprehensive genome profiling for treatment-refractory cases Hirayama, Yukiyoshi Kato, Minoru Kimura, Kaoru Otoshi, Taiyo Yamasaki, Takeshi Uchida, Junji Urol Case Rep Oncology Herein, we report a case of a 59-year-old man with advanced castration-resistant prostate cancer with rectal invasion. Multimodal treatment, including drug therapy, surgery, and radiation therapy was sequentially performed; however, lymph node metastases repeatedly occurred. Tumor genomic profiling using FoundationOne CDx identified pathogenic alterations in three DNA repair genes, including BRCA2 frameshift mutation. Olaparib, a poly-ADP ribose polymerase inhibitor, showed marked response. Castration-resistant prostate cancer with multiple DNA repair genes was successfully treated with olaparib; comprehensive genome profiling can lead to its optimal clinical management. Elsevier 2022-08-30 /pmc/articles/PMC9460157/ /pubmed/36092022 http://dx.doi.org/10.1016/j.eucr.2022.102210 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Oncology
Hirayama, Yukiyoshi
Kato, Minoru
Kimura, Kaoru
Otoshi, Taiyo
Yamasaki, Takeshi
Uchida, Junji
Successful case of olaparib treatment for castration-resistant prostate cancer with multiple DNA repair gene mutations: Use of comprehensive genome profiling for treatment-refractory cases
title Successful case of olaparib treatment for castration-resistant prostate cancer with multiple DNA repair gene mutations: Use of comprehensive genome profiling for treatment-refractory cases
title_full Successful case of olaparib treatment for castration-resistant prostate cancer with multiple DNA repair gene mutations: Use of comprehensive genome profiling for treatment-refractory cases
title_fullStr Successful case of olaparib treatment for castration-resistant prostate cancer with multiple DNA repair gene mutations: Use of comprehensive genome profiling for treatment-refractory cases
title_full_unstemmed Successful case of olaparib treatment for castration-resistant prostate cancer with multiple DNA repair gene mutations: Use of comprehensive genome profiling for treatment-refractory cases
title_short Successful case of olaparib treatment for castration-resistant prostate cancer with multiple DNA repair gene mutations: Use of comprehensive genome profiling for treatment-refractory cases
title_sort successful case of olaparib treatment for castration-resistant prostate cancer with multiple dna repair gene mutations: use of comprehensive genome profiling for treatment-refractory cases
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9460157/
https://www.ncbi.nlm.nih.gov/pubmed/36092022
http://dx.doi.org/10.1016/j.eucr.2022.102210
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