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Synthetic refactor of essential genes decodes functionally constrained sequences in yeast genome
The relationship between gene sequence and function matters for fundamental and practical reasons. Here, yeast essential genes were systematically refactored to identify invariable sequences in the coding and regulatory regions. The coding sequences were synonymously recoded with all optimal codons...
| Autores principales: | , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9460170/ https://www.ncbi.nlm.nih.gov/pubmed/36093046 http://dx.doi.org/10.1016/j.isci.2022.104982 |