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Metabologenomic Approach Reveals Intestinal Environmental Features Associated with Barley-Induced Glucose Tolerance Improvements in Japanese: A Randomized Controlled Trial

(1) Background: Consumption of barley has been known to exert beneficial effects on glucose tolerance; however, it has also been reported that there are inter-individual differences in these responses. Recent evidence has suggested that these individual differences are mediated by the gut microbiota...

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Autores principales: Goto, Yuka, Nishimoto, Yuichiro, Murakami, Shinnosuke, Nomaguchi, Tatsuhiro, Mori, Yuka, Ito, Masaki, Nakaguro, Ryohei, Kudo, Toru, Matsuoka, Tsubasa, Yamada, Takuji, Kobayashi, Toshiki, Fukuda, Shinji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9460218/
https://www.ncbi.nlm.nih.gov/pubmed/36079725
http://dx.doi.org/10.3390/nu14173468
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author Goto, Yuka
Nishimoto, Yuichiro
Murakami, Shinnosuke
Nomaguchi, Tatsuhiro
Mori, Yuka
Ito, Masaki
Nakaguro, Ryohei
Kudo, Toru
Matsuoka, Tsubasa
Yamada, Takuji
Kobayashi, Toshiki
Fukuda, Shinji
author_facet Goto, Yuka
Nishimoto, Yuichiro
Murakami, Shinnosuke
Nomaguchi, Tatsuhiro
Mori, Yuka
Ito, Masaki
Nakaguro, Ryohei
Kudo, Toru
Matsuoka, Tsubasa
Yamada, Takuji
Kobayashi, Toshiki
Fukuda, Shinji
author_sort Goto, Yuka
collection PubMed
description (1) Background: Consumption of barley has been known to exert beneficial effects on glucose tolerance; however, it has also been reported that there are inter-individual differences in these responses. Recent evidence has suggested that these individual differences are mediated by the gut microbiota. (2) Methods: In the present study, we aimed to understand the relationship between the intestinal environment, including intestinal microbiome and their metabolome, and glucose tolerance. A randomized controlled trial with a 4-week consumption of barley or control food was conducted. We conducted an integrated analysis of the intestinal microbiome and metabolome and analyzed the relationship with improvement of glucose tolerance. (3) Results: We found that metabolites such as azelate were significantly increased after barley consumption. Furthermore, the subjects whose glucose tolerance was slightly impaired showed improvement in their glucose tolerance index following the barley consumption. Additionally, the analysis showed that the increase in the abundance of the Anaerostipes was correlated with the improvement in the glucose tolerance index. (4) Conclusions: Our findings indicate that the effects of barley consumption for glucose tolerance are partly defined by the intestinal environment of consumers, providing a quantitative measurement of the dietary effect based on the intestinal environment.
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spelling pubmed-94602182022-09-10 Metabologenomic Approach Reveals Intestinal Environmental Features Associated with Barley-Induced Glucose Tolerance Improvements in Japanese: A Randomized Controlled Trial Goto, Yuka Nishimoto, Yuichiro Murakami, Shinnosuke Nomaguchi, Tatsuhiro Mori, Yuka Ito, Masaki Nakaguro, Ryohei Kudo, Toru Matsuoka, Tsubasa Yamada, Takuji Kobayashi, Toshiki Fukuda, Shinji Nutrients Article (1) Background: Consumption of barley has been known to exert beneficial effects on glucose tolerance; however, it has also been reported that there are inter-individual differences in these responses. Recent evidence has suggested that these individual differences are mediated by the gut microbiota. (2) Methods: In the present study, we aimed to understand the relationship between the intestinal environment, including intestinal microbiome and their metabolome, and glucose tolerance. A randomized controlled trial with a 4-week consumption of barley or control food was conducted. We conducted an integrated analysis of the intestinal microbiome and metabolome and analyzed the relationship with improvement of glucose tolerance. (3) Results: We found that metabolites such as azelate were significantly increased after barley consumption. Furthermore, the subjects whose glucose tolerance was slightly impaired showed improvement in their glucose tolerance index following the barley consumption. Additionally, the analysis showed that the increase in the abundance of the Anaerostipes was correlated with the improvement in the glucose tolerance index. (4) Conclusions: Our findings indicate that the effects of barley consumption for glucose tolerance are partly defined by the intestinal environment of consumers, providing a quantitative measurement of the dietary effect based on the intestinal environment. MDPI 2022-08-24 /pmc/articles/PMC9460218/ /pubmed/36079725 http://dx.doi.org/10.3390/nu14173468 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Goto, Yuka
Nishimoto, Yuichiro
Murakami, Shinnosuke
Nomaguchi, Tatsuhiro
Mori, Yuka
Ito, Masaki
Nakaguro, Ryohei
Kudo, Toru
Matsuoka, Tsubasa
Yamada, Takuji
Kobayashi, Toshiki
Fukuda, Shinji
Metabologenomic Approach Reveals Intestinal Environmental Features Associated with Barley-Induced Glucose Tolerance Improvements in Japanese: A Randomized Controlled Trial
title Metabologenomic Approach Reveals Intestinal Environmental Features Associated with Barley-Induced Glucose Tolerance Improvements in Japanese: A Randomized Controlled Trial
title_full Metabologenomic Approach Reveals Intestinal Environmental Features Associated with Barley-Induced Glucose Tolerance Improvements in Japanese: A Randomized Controlled Trial
title_fullStr Metabologenomic Approach Reveals Intestinal Environmental Features Associated with Barley-Induced Glucose Tolerance Improvements in Japanese: A Randomized Controlled Trial
title_full_unstemmed Metabologenomic Approach Reveals Intestinal Environmental Features Associated with Barley-Induced Glucose Tolerance Improvements in Japanese: A Randomized Controlled Trial
title_short Metabologenomic Approach Reveals Intestinal Environmental Features Associated with Barley-Induced Glucose Tolerance Improvements in Japanese: A Randomized Controlled Trial
title_sort metabologenomic approach reveals intestinal environmental features associated with barley-induced glucose tolerance improvements in japanese: a randomized controlled trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9460218/
https://www.ncbi.nlm.nih.gov/pubmed/36079725
http://dx.doi.org/10.3390/nu14173468
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