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Bioresponsive Polymers for Nanomedicine—Expectations and Reality!

Bioresponsive polymers in nanomedicine have been widely perceived to selectively activate the therapeutic function of nanomedicine at diseased or pathological sites, while sparing their healthy counterparts. This idea can be described as an advanced version of Paul Ehrlich’s magic bullet concept. Fr...

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Detalles Bibliográficos
Autores principales: Quader, Sabina, Van Guyse, Joachim F. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9460233/
https://www.ncbi.nlm.nih.gov/pubmed/36080733
http://dx.doi.org/10.3390/polym14173659
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author Quader, Sabina
Van Guyse, Joachim F. R.
author_facet Quader, Sabina
Van Guyse, Joachim F. R.
author_sort Quader, Sabina
collection PubMed
description Bioresponsive polymers in nanomedicine have been widely perceived to selectively activate the therapeutic function of nanomedicine at diseased or pathological sites, while sparing their healthy counterparts. This idea can be described as an advanced version of Paul Ehrlich’s magic bullet concept. From that perspective, the inherent anomalies or malfunction of the pathological sites are generally targeted to allow the selective activation or sensory function of nanomedicine. Nonetheless, while the primary goals and expectations in developing bioresponsive polymers are to elicit exclusive selectivity of therapeutic action at diseased sites, this remains difficult to achieve in practice. Numerous research efforts have been undertaken, and are ongoing, to tackle this fine-tuning. This review provides a brief introduction to key stimuli with biological relevance commonly featured in the design of bioresponsive polymers, which serves as a platform for critical discussion, and identifies the gap between expectations and current reality.
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spelling pubmed-94602332022-09-10 Bioresponsive Polymers for Nanomedicine—Expectations and Reality! Quader, Sabina Van Guyse, Joachim F. R. Polymers (Basel) Review Bioresponsive polymers in nanomedicine have been widely perceived to selectively activate the therapeutic function of nanomedicine at diseased or pathological sites, while sparing their healthy counterparts. This idea can be described as an advanced version of Paul Ehrlich’s magic bullet concept. From that perspective, the inherent anomalies or malfunction of the pathological sites are generally targeted to allow the selective activation or sensory function of nanomedicine. Nonetheless, while the primary goals and expectations in developing bioresponsive polymers are to elicit exclusive selectivity of therapeutic action at diseased sites, this remains difficult to achieve in practice. Numerous research efforts have been undertaken, and are ongoing, to tackle this fine-tuning. This review provides a brief introduction to key stimuli with biological relevance commonly featured in the design of bioresponsive polymers, which serves as a platform for critical discussion, and identifies the gap between expectations and current reality. MDPI 2022-09-03 /pmc/articles/PMC9460233/ /pubmed/36080733 http://dx.doi.org/10.3390/polym14173659 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Quader, Sabina
Van Guyse, Joachim F. R.
Bioresponsive Polymers for Nanomedicine—Expectations and Reality!
title Bioresponsive Polymers for Nanomedicine—Expectations and Reality!
title_full Bioresponsive Polymers for Nanomedicine—Expectations and Reality!
title_fullStr Bioresponsive Polymers for Nanomedicine—Expectations and Reality!
title_full_unstemmed Bioresponsive Polymers for Nanomedicine—Expectations and Reality!
title_short Bioresponsive Polymers for Nanomedicine—Expectations and Reality!
title_sort bioresponsive polymers for nanomedicine—expectations and reality!
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9460233/
https://www.ncbi.nlm.nih.gov/pubmed/36080733
http://dx.doi.org/10.3390/polym14173659
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