Cargando…

The Role of a Polymer-Based E-Nose in the Detection of Head and Neck Cancer from Exhaled Breath

The aim of our study was to assess whether a polymer-based e-nose can distinguish head and neck cancer subjects from healthy controls, as well as from patients with allergic rhinitis. A total number of 45 subjects participated in this study. The first group was composed of 15 patients with histology...

Descripción completa

Detalles Bibliográficos
Autores principales: Anzivino, Roberta, Sciancalepore, Pasqua Irene, Dragonieri, Silvano, Quaranta, Vitaliano Nicola, Petrone, Paolo, Petrone, Domenico, Quaranta, Nicola, Carpagnano, Giovanna Elisiana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9460264/
https://www.ncbi.nlm.nih.gov/pubmed/36080944
http://dx.doi.org/10.3390/s22176485
_version_ 1784786704585981952
author Anzivino, Roberta
Sciancalepore, Pasqua Irene
Dragonieri, Silvano
Quaranta, Vitaliano Nicola
Petrone, Paolo
Petrone, Domenico
Quaranta, Nicola
Carpagnano, Giovanna Elisiana
author_facet Anzivino, Roberta
Sciancalepore, Pasqua Irene
Dragonieri, Silvano
Quaranta, Vitaliano Nicola
Petrone, Paolo
Petrone, Domenico
Quaranta, Nicola
Carpagnano, Giovanna Elisiana
author_sort Anzivino, Roberta
collection PubMed
description The aim of our study was to assess whether a polymer-based e-nose can distinguish head and neck cancer subjects from healthy controls, as well as from patients with allergic rhinitis. A total number of 45 subjects participated in this study. The first group was composed of 15 patients with histology confirmed diagnosis of head and neck cancer. The second group was made up of 15 patients with diagnoses of allergic rhinitis. The control group consisted of 15 subjects with a negative history of upper airways and/or chest symptoms. Exhaled breath was collected from all participants and sampled by a polymer-based e-nose (Cyranose 320, Sensigent, Pasadena, CA, USA). In the Principal Component Analysis plot, patients with head and neck cancer clustered distinctly from the controls as well as from patients with allergic rhinitis. Using canonical discriminant analysis, the three groups were discriminated, with a cross validated accuracy% of 75.1, p < 0.01. The area under the curve of the receiver operating characteristic curve for the discrimination between head and neck cancer patients and the other groups was 0.87. To conclude, e-nose technology has the potential for application in the diagnosis of head and neck cancer, being an easy, quick, non-invasive and cost-effective tool.
format Online
Article
Text
id pubmed-9460264
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-94602642022-09-10 The Role of a Polymer-Based E-Nose in the Detection of Head and Neck Cancer from Exhaled Breath Anzivino, Roberta Sciancalepore, Pasqua Irene Dragonieri, Silvano Quaranta, Vitaliano Nicola Petrone, Paolo Petrone, Domenico Quaranta, Nicola Carpagnano, Giovanna Elisiana Sensors (Basel) Communication The aim of our study was to assess whether a polymer-based e-nose can distinguish head and neck cancer subjects from healthy controls, as well as from patients with allergic rhinitis. A total number of 45 subjects participated in this study. The first group was composed of 15 patients with histology confirmed diagnosis of head and neck cancer. The second group was made up of 15 patients with diagnoses of allergic rhinitis. The control group consisted of 15 subjects with a negative history of upper airways and/or chest symptoms. Exhaled breath was collected from all participants and sampled by a polymer-based e-nose (Cyranose 320, Sensigent, Pasadena, CA, USA). In the Principal Component Analysis plot, patients with head and neck cancer clustered distinctly from the controls as well as from patients with allergic rhinitis. Using canonical discriminant analysis, the three groups were discriminated, with a cross validated accuracy% of 75.1, p < 0.01. The area under the curve of the receiver operating characteristic curve for the discrimination between head and neck cancer patients and the other groups was 0.87. To conclude, e-nose technology has the potential for application in the diagnosis of head and neck cancer, being an easy, quick, non-invasive and cost-effective tool. MDPI 2022-08-29 /pmc/articles/PMC9460264/ /pubmed/36080944 http://dx.doi.org/10.3390/s22176485 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Anzivino, Roberta
Sciancalepore, Pasqua Irene
Dragonieri, Silvano
Quaranta, Vitaliano Nicola
Petrone, Paolo
Petrone, Domenico
Quaranta, Nicola
Carpagnano, Giovanna Elisiana
The Role of a Polymer-Based E-Nose in the Detection of Head and Neck Cancer from Exhaled Breath
title The Role of a Polymer-Based E-Nose in the Detection of Head and Neck Cancer from Exhaled Breath
title_full The Role of a Polymer-Based E-Nose in the Detection of Head and Neck Cancer from Exhaled Breath
title_fullStr The Role of a Polymer-Based E-Nose in the Detection of Head and Neck Cancer from Exhaled Breath
title_full_unstemmed The Role of a Polymer-Based E-Nose in the Detection of Head and Neck Cancer from Exhaled Breath
title_short The Role of a Polymer-Based E-Nose in the Detection of Head and Neck Cancer from Exhaled Breath
title_sort role of a polymer-based e-nose in the detection of head and neck cancer from exhaled breath
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9460264/
https://www.ncbi.nlm.nih.gov/pubmed/36080944
http://dx.doi.org/10.3390/s22176485
work_keys_str_mv AT anzivinoroberta theroleofapolymerbasedenoseinthedetectionofheadandneckcancerfromexhaledbreath
AT sciancaleporepasquairene theroleofapolymerbasedenoseinthedetectionofheadandneckcancerfromexhaledbreath
AT dragonierisilvano theroleofapolymerbasedenoseinthedetectionofheadandneckcancerfromexhaledbreath
AT quarantavitalianonicola theroleofapolymerbasedenoseinthedetectionofheadandneckcancerfromexhaledbreath
AT petronepaolo theroleofapolymerbasedenoseinthedetectionofheadandneckcancerfromexhaledbreath
AT petronedomenico theroleofapolymerbasedenoseinthedetectionofheadandneckcancerfromexhaledbreath
AT quarantanicola theroleofapolymerbasedenoseinthedetectionofheadandneckcancerfromexhaledbreath
AT carpagnanogiovannaelisiana theroleofapolymerbasedenoseinthedetectionofheadandneckcancerfromexhaledbreath
AT anzivinoroberta roleofapolymerbasedenoseinthedetectionofheadandneckcancerfromexhaledbreath
AT sciancaleporepasquairene roleofapolymerbasedenoseinthedetectionofheadandneckcancerfromexhaledbreath
AT dragonierisilvano roleofapolymerbasedenoseinthedetectionofheadandneckcancerfromexhaledbreath
AT quarantavitalianonicola roleofapolymerbasedenoseinthedetectionofheadandneckcancerfromexhaledbreath
AT petronepaolo roleofapolymerbasedenoseinthedetectionofheadandneckcancerfromexhaledbreath
AT petronedomenico roleofapolymerbasedenoseinthedetectionofheadandneckcancerfromexhaledbreath
AT quarantanicola roleofapolymerbasedenoseinthedetectionofheadandneckcancerfromexhaledbreath
AT carpagnanogiovannaelisiana roleofapolymerbasedenoseinthedetectionofheadandneckcancerfromexhaledbreath