Cargando…
The Role of a Polymer-Based E-Nose in the Detection of Head and Neck Cancer from Exhaled Breath
The aim of our study was to assess whether a polymer-based e-nose can distinguish head and neck cancer subjects from healthy controls, as well as from patients with allergic rhinitis. A total number of 45 subjects participated in this study. The first group was composed of 15 patients with histology...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9460264/ https://www.ncbi.nlm.nih.gov/pubmed/36080944 http://dx.doi.org/10.3390/s22176485 |
_version_ | 1784786704585981952 |
---|---|
author | Anzivino, Roberta Sciancalepore, Pasqua Irene Dragonieri, Silvano Quaranta, Vitaliano Nicola Petrone, Paolo Petrone, Domenico Quaranta, Nicola Carpagnano, Giovanna Elisiana |
author_facet | Anzivino, Roberta Sciancalepore, Pasqua Irene Dragonieri, Silvano Quaranta, Vitaliano Nicola Petrone, Paolo Petrone, Domenico Quaranta, Nicola Carpagnano, Giovanna Elisiana |
author_sort | Anzivino, Roberta |
collection | PubMed |
description | The aim of our study was to assess whether a polymer-based e-nose can distinguish head and neck cancer subjects from healthy controls, as well as from patients with allergic rhinitis. A total number of 45 subjects participated in this study. The first group was composed of 15 patients with histology confirmed diagnosis of head and neck cancer. The second group was made up of 15 patients with diagnoses of allergic rhinitis. The control group consisted of 15 subjects with a negative history of upper airways and/or chest symptoms. Exhaled breath was collected from all participants and sampled by a polymer-based e-nose (Cyranose 320, Sensigent, Pasadena, CA, USA). In the Principal Component Analysis plot, patients with head and neck cancer clustered distinctly from the controls as well as from patients with allergic rhinitis. Using canonical discriminant analysis, the three groups were discriminated, with a cross validated accuracy% of 75.1, p < 0.01. The area under the curve of the receiver operating characteristic curve for the discrimination between head and neck cancer patients and the other groups was 0.87. To conclude, e-nose technology has the potential for application in the diagnosis of head and neck cancer, being an easy, quick, non-invasive and cost-effective tool. |
format | Online Article Text |
id | pubmed-9460264 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94602642022-09-10 The Role of a Polymer-Based E-Nose in the Detection of Head and Neck Cancer from Exhaled Breath Anzivino, Roberta Sciancalepore, Pasqua Irene Dragonieri, Silvano Quaranta, Vitaliano Nicola Petrone, Paolo Petrone, Domenico Quaranta, Nicola Carpagnano, Giovanna Elisiana Sensors (Basel) Communication The aim of our study was to assess whether a polymer-based e-nose can distinguish head and neck cancer subjects from healthy controls, as well as from patients with allergic rhinitis. A total number of 45 subjects participated in this study. The first group was composed of 15 patients with histology confirmed diagnosis of head and neck cancer. The second group was made up of 15 patients with diagnoses of allergic rhinitis. The control group consisted of 15 subjects with a negative history of upper airways and/or chest symptoms. Exhaled breath was collected from all participants and sampled by a polymer-based e-nose (Cyranose 320, Sensigent, Pasadena, CA, USA). In the Principal Component Analysis plot, patients with head and neck cancer clustered distinctly from the controls as well as from patients with allergic rhinitis. Using canonical discriminant analysis, the three groups were discriminated, with a cross validated accuracy% of 75.1, p < 0.01. The area under the curve of the receiver operating characteristic curve for the discrimination between head and neck cancer patients and the other groups was 0.87. To conclude, e-nose technology has the potential for application in the diagnosis of head and neck cancer, being an easy, quick, non-invasive and cost-effective tool. MDPI 2022-08-29 /pmc/articles/PMC9460264/ /pubmed/36080944 http://dx.doi.org/10.3390/s22176485 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Anzivino, Roberta Sciancalepore, Pasqua Irene Dragonieri, Silvano Quaranta, Vitaliano Nicola Petrone, Paolo Petrone, Domenico Quaranta, Nicola Carpagnano, Giovanna Elisiana The Role of a Polymer-Based E-Nose in the Detection of Head and Neck Cancer from Exhaled Breath |
title | The Role of a Polymer-Based E-Nose in the Detection of Head and Neck Cancer from Exhaled Breath |
title_full | The Role of a Polymer-Based E-Nose in the Detection of Head and Neck Cancer from Exhaled Breath |
title_fullStr | The Role of a Polymer-Based E-Nose in the Detection of Head and Neck Cancer from Exhaled Breath |
title_full_unstemmed | The Role of a Polymer-Based E-Nose in the Detection of Head and Neck Cancer from Exhaled Breath |
title_short | The Role of a Polymer-Based E-Nose in the Detection of Head and Neck Cancer from Exhaled Breath |
title_sort | role of a polymer-based e-nose in the detection of head and neck cancer from exhaled breath |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9460264/ https://www.ncbi.nlm.nih.gov/pubmed/36080944 http://dx.doi.org/10.3390/s22176485 |
work_keys_str_mv | AT anzivinoroberta theroleofapolymerbasedenoseinthedetectionofheadandneckcancerfromexhaledbreath AT sciancaleporepasquairene theroleofapolymerbasedenoseinthedetectionofheadandneckcancerfromexhaledbreath AT dragonierisilvano theroleofapolymerbasedenoseinthedetectionofheadandneckcancerfromexhaledbreath AT quarantavitalianonicola theroleofapolymerbasedenoseinthedetectionofheadandneckcancerfromexhaledbreath AT petronepaolo theroleofapolymerbasedenoseinthedetectionofheadandneckcancerfromexhaledbreath AT petronedomenico theroleofapolymerbasedenoseinthedetectionofheadandneckcancerfromexhaledbreath AT quarantanicola theroleofapolymerbasedenoseinthedetectionofheadandneckcancerfromexhaledbreath AT carpagnanogiovannaelisiana theroleofapolymerbasedenoseinthedetectionofheadandneckcancerfromexhaledbreath AT anzivinoroberta roleofapolymerbasedenoseinthedetectionofheadandneckcancerfromexhaledbreath AT sciancaleporepasquairene roleofapolymerbasedenoseinthedetectionofheadandneckcancerfromexhaledbreath AT dragonierisilvano roleofapolymerbasedenoseinthedetectionofheadandneckcancerfromexhaledbreath AT quarantavitalianonicola roleofapolymerbasedenoseinthedetectionofheadandneckcancerfromexhaledbreath AT petronepaolo roleofapolymerbasedenoseinthedetectionofheadandneckcancerfromexhaledbreath AT petronedomenico roleofapolymerbasedenoseinthedetectionofheadandneckcancerfromexhaledbreath AT quarantanicola roleofapolymerbasedenoseinthedetectionofheadandneckcancerfromexhaledbreath AT carpagnanogiovannaelisiana roleofapolymerbasedenoseinthedetectionofheadandneckcancerfromexhaledbreath |