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Inverse Association between Serum Selenium Level and Severity of Liver Fibrosis: A Cross-Sectional Study

Selenium has been well recognized for its important role in human health. Prior studies showed that low serum selenium was associated with various diseases, including cardiovascular disease, cancer, infertility, and cognitive decline. Recent studies demonstrated an association between selenium defic...

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Autores principales: Shih, Chi-Wei, Chen, Ying-Jen, Chen, Wei-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9460482/
https://www.ncbi.nlm.nih.gov/pubmed/36079882
http://dx.doi.org/10.3390/nu14173625
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author Shih, Chi-Wei
Chen, Ying-Jen
Chen, Wei-Liang
author_facet Shih, Chi-Wei
Chen, Ying-Jen
Chen, Wei-Liang
author_sort Shih, Chi-Wei
collection PubMed
description Selenium has been well recognized for its important role in human health. Prior studies showed that low serum selenium was associated with various diseases, including cardiovascular disease, cancer, infertility, and cognitive decline. Recent studies demonstrated an association between selenium deficiency and liver cirrhosis. In our study, we aimed to explore the association between serum selenium levels and severity of liver fibrosis. In total, 5641 participants at an age of 12 and above, from the 2017–2018 United States National Health and Nutrition Examination Survey, were enrolled. The severity of liver fibrosis was determined by liver ultrasound transient elastography. There was a significant linear decrease in liver stiffness measurement (LSM) values in male groups with increased serum selenium levels. The beta coefficient (β) = −1.045 in male groups. A significantly negative association was also observed in the group of age ≥ 60. In addition, those in the highest quartile of serum selenium had lower LSM values (β = −0.416). This is the first study using LSM to demonstrate the correlation between selenium deficiency and severity of liver cirrhosis. Our findings suggest that a high plasma selenium concentration is negatively correlated with the severity of liver cirrhosis and there are gender and age differences.
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spelling pubmed-94604822022-09-10 Inverse Association between Serum Selenium Level and Severity of Liver Fibrosis: A Cross-Sectional Study Shih, Chi-Wei Chen, Ying-Jen Chen, Wei-Liang Nutrients Article Selenium has been well recognized for its important role in human health. Prior studies showed that low serum selenium was associated with various diseases, including cardiovascular disease, cancer, infertility, and cognitive decline. Recent studies demonstrated an association between selenium deficiency and liver cirrhosis. In our study, we aimed to explore the association between serum selenium levels and severity of liver fibrosis. In total, 5641 participants at an age of 12 and above, from the 2017–2018 United States National Health and Nutrition Examination Survey, were enrolled. The severity of liver fibrosis was determined by liver ultrasound transient elastography. There was a significant linear decrease in liver stiffness measurement (LSM) values in male groups with increased serum selenium levels. The beta coefficient (β) = −1.045 in male groups. A significantly negative association was also observed in the group of age ≥ 60. In addition, those in the highest quartile of serum selenium had lower LSM values (β = −0.416). This is the first study using LSM to demonstrate the correlation between selenium deficiency and severity of liver cirrhosis. Our findings suggest that a high plasma selenium concentration is negatively correlated with the severity of liver cirrhosis and there are gender and age differences. MDPI 2022-09-02 /pmc/articles/PMC9460482/ /pubmed/36079882 http://dx.doi.org/10.3390/nu14173625 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shih, Chi-Wei
Chen, Ying-Jen
Chen, Wei-Liang
Inverse Association between Serum Selenium Level and Severity of Liver Fibrosis: A Cross-Sectional Study
title Inverse Association between Serum Selenium Level and Severity of Liver Fibrosis: A Cross-Sectional Study
title_full Inverse Association between Serum Selenium Level and Severity of Liver Fibrosis: A Cross-Sectional Study
title_fullStr Inverse Association between Serum Selenium Level and Severity of Liver Fibrosis: A Cross-Sectional Study
title_full_unstemmed Inverse Association between Serum Selenium Level and Severity of Liver Fibrosis: A Cross-Sectional Study
title_short Inverse Association between Serum Selenium Level and Severity of Liver Fibrosis: A Cross-Sectional Study
title_sort inverse association between serum selenium level and severity of liver fibrosis: a cross-sectional study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9460482/
https://www.ncbi.nlm.nih.gov/pubmed/36079882
http://dx.doi.org/10.3390/nu14173625
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