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The 5′-phosphate enhances the DNA-binding and exonuclease activities of human mitochondrial genome maintenance exonuclease 1 (MGME1)

In higher eukaryotes, mitochondria play multiple roles in energy production, signaling, and biosynthesis. Mitochondria possess multiple copies of mitochondrial DNA (mtDNA), which encodes 37 genes that are essential for mitochondrial and cellular function. When mtDNA is challenged by endogenous and e...

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Detalles Bibliográficos
Autores principales:	Urrutia, Kathleen M., Xu, Wenyan, Zhao, Linlin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9460513/ https://www.ncbi.nlm.nih.gov/pubmed/35934053 http://dx.doi.org/10.1016/j.jbc.2022.102306

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