Probabilistic boolean networks predict transcription factor targets to induce transdifferentiation

We developed a computational approach to find the best intervention to achieve transcription factor (TF) mediated transdifferentiation. We construct probabilistic Boolean networks (PBNs) from single-cell RNA sequencing data of two different cell states to model hematopoietic transcription factors cr...

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Detalles Bibliográficos
Autores principales: Tercan, Bahar, Aguilar, Boris, Huang, Sui, Dougherty, Edward R., Shmulevich, Ilya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9460527/
https://www.ncbi.nlm.nih.gov/pubmed/36093045
http://dx.doi.org/10.1016/j.isci.2022.104951

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9460527/
https://www.ncbi.nlm.nih.gov/pubmed/36093045
http://dx.doi.org/10.1016/j.isci.2022.104951

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