Cargando…
Associations of Dietary Macroelements with Knee Joint Structures, Symptoms, Quality of Life, and Comorbid Conditions in People with Symptomatic Knee Osteoarthritis
Background: Osteoarthritis (OA), the most common joint disease in the elderly, has no cure. Macroelements are vital in human health and their relationships with OA are not clear. Clarifying the relationships between macroelements and OA may assist knee OA management. Methods: This study was a post-h...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9460692/ https://www.ncbi.nlm.nih.gov/pubmed/36079832 http://dx.doi.org/10.3390/nu14173576 |
_version_ | 1784786809489719296 |
---|---|
author | Zhang, Yan Chen, Tianyu Luo, Ping Li, Shengfa Zhu, Jianwei Xue, Song Cao, Peihua Zhu, Zhaohua Li, Jia Wang, Xiaoshuai Wluka, Anita E. Cicuttini, Flavia Ruan, Guangfeng Ding, Changhai |
author_facet | Zhang, Yan Chen, Tianyu Luo, Ping Li, Shengfa Zhu, Jianwei Xue, Song Cao, Peihua Zhu, Zhaohua Li, Jia Wang, Xiaoshuai Wluka, Anita E. Cicuttini, Flavia Ruan, Guangfeng Ding, Changhai |
author_sort | Zhang, Yan |
collection | PubMed |
description | Background: Osteoarthritis (OA), the most common joint disease in the elderly, has no cure. Macroelements are vital in human health and their relationships with OA are not clear. Clarifying the relationships between macroelements and OA may assist knee OA management. Methods: This study was a post-hoc analysis using data from a two-year randomized controlled trial among 392 participants with knee OA. Dietary macroelements, including calcium, magnesium, potassium, and phosphorus were computed-based on a semi-quantitative food frequency questionnaire at baseline. Knee joint structures (including cartilage volume, cartilage defect, bone marrow lesions, and effusion-synovitis volume), OA symptoms, quality of life, and OA comorbid conditions (including lower limb muscle strength and depressive symptoms) were assessed at baseline and month 24. Western Ontario and McMaster Universities (WOMAC) Index and depressive symptoms were assessed at baseline and months 3, 6, 12, and 24. Quality of life and lower limb muscle strength were assessed at baseline and months 6, 12, and 24. All analyses were conducted using mixed-effects models. Results: Higher dietary magnesium and potassium were associated with fewer OA symptoms, higher quality of life, greater lower limb muscle strength, and fewer depressive symptoms, but not with knee joint structures. Higher dietary calcium and phosphorus was not associated with any of the OA-related outcomes, except that dietary phosphorus was associated with greater lower limb muscle strength. Conclusions: In the longitudinal analyses, higher dietary magnesium and potassium intake are associated with fewer OA symptoms, higher quality of life, and milder comorbid conditions in patients with knee OA, suggesting dietary magnesium and potassium may have beneficial effects on OA and could be used for knee OA management. |
format | Online Article Text |
id | pubmed-9460692 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94606922022-09-10 Associations of Dietary Macroelements with Knee Joint Structures, Symptoms, Quality of Life, and Comorbid Conditions in People with Symptomatic Knee Osteoarthritis Zhang, Yan Chen, Tianyu Luo, Ping Li, Shengfa Zhu, Jianwei Xue, Song Cao, Peihua Zhu, Zhaohua Li, Jia Wang, Xiaoshuai Wluka, Anita E. Cicuttini, Flavia Ruan, Guangfeng Ding, Changhai Nutrients Article Background: Osteoarthritis (OA), the most common joint disease in the elderly, has no cure. Macroelements are vital in human health and their relationships with OA are not clear. Clarifying the relationships between macroelements and OA may assist knee OA management. Methods: This study was a post-hoc analysis using data from a two-year randomized controlled trial among 392 participants with knee OA. Dietary macroelements, including calcium, magnesium, potassium, and phosphorus were computed-based on a semi-quantitative food frequency questionnaire at baseline. Knee joint structures (including cartilage volume, cartilage defect, bone marrow lesions, and effusion-synovitis volume), OA symptoms, quality of life, and OA comorbid conditions (including lower limb muscle strength and depressive symptoms) were assessed at baseline and month 24. Western Ontario and McMaster Universities (WOMAC) Index and depressive symptoms were assessed at baseline and months 3, 6, 12, and 24. Quality of life and lower limb muscle strength were assessed at baseline and months 6, 12, and 24. All analyses were conducted using mixed-effects models. Results: Higher dietary magnesium and potassium were associated with fewer OA symptoms, higher quality of life, greater lower limb muscle strength, and fewer depressive symptoms, but not with knee joint structures. Higher dietary calcium and phosphorus was not associated with any of the OA-related outcomes, except that dietary phosphorus was associated with greater lower limb muscle strength. Conclusions: In the longitudinal analyses, higher dietary magnesium and potassium intake are associated with fewer OA symptoms, higher quality of life, and milder comorbid conditions in patients with knee OA, suggesting dietary magnesium and potassium may have beneficial effects on OA and could be used for knee OA management. MDPI 2022-08-30 /pmc/articles/PMC9460692/ /pubmed/36079832 http://dx.doi.org/10.3390/nu14173576 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zhang, Yan Chen, Tianyu Luo, Ping Li, Shengfa Zhu, Jianwei Xue, Song Cao, Peihua Zhu, Zhaohua Li, Jia Wang, Xiaoshuai Wluka, Anita E. Cicuttini, Flavia Ruan, Guangfeng Ding, Changhai Associations of Dietary Macroelements with Knee Joint Structures, Symptoms, Quality of Life, and Comorbid Conditions in People with Symptomatic Knee Osteoarthritis |
title | Associations of Dietary Macroelements with Knee Joint Structures, Symptoms, Quality of Life, and Comorbid Conditions in People with Symptomatic Knee Osteoarthritis |
title_full | Associations of Dietary Macroelements with Knee Joint Structures, Symptoms, Quality of Life, and Comorbid Conditions in People with Symptomatic Knee Osteoarthritis |
title_fullStr | Associations of Dietary Macroelements with Knee Joint Structures, Symptoms, Quality of Life, and Comorbid Conditions in People with Symptomatic Knee Osteoarthritis |
title_full_unstemmed | Associations of Dietary Macroelements with Knee Joint Structures, Symptoms, Quality of Life, and Comorbid Conditions in People with Symptomatic Knee Osteoarthritis |
title_short | Associations of Dietary Macroelements with Knee Joint Structures, Symptoms, Quality of Life, and Comorbid Conditions in People with Symptomatic Knee Osteoarthritis |
title_sort | associations of dietary macroelements with knee joint structures, symptoms, quality of life, and comorbid conditions in people with symptomatic knee osteoarthritis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9460692/ https://www.ncbi.nlm.nih.gov/pubmed/36079832 http://dx.doi.org/10.3390/nu14173576 |
work_keys_str_mv | AT zhangyan associationsofdietarymacroelementswithkneejointstructuressymptomsqualityoflifeandcomorbidconditionsinpeoplewithsymptomatickneeosteoarthritis AT chentianyu associationsofdietarymacroelementswithkneejointstructuressymptomsqualityoflifeandcomorbidconditionsinpeoplewithsymptomatickneeosteoarthritis AT luoping associationsofdietarymacroelementswithkneejointstructuressymptomsqualityoflifeandcomorbidconditionsinpeoplewithsymptomatickneeosteoarthritis AT lishengfa associationsofdietarymacroelementswithkneejointstructuressymptomsqualityoflifeandcomorbidconditionsinpeoplewithsymptomatickneeosteoarthritis AT zhujianwei associationsofdietarymacroelementswithkneejointstructuressymptomsqualityoflifeandcomorbidconditionsinpeoplewithsymptomatickneeosteoarthritis AT xuesong associationsofdietarymacroelementswithkneejointstructuressymptomsqualityoflifeandcomorbidconditionsinpeoplewithsymptomatickneeosteoarthritis AT caopeihua associationsofdietarymacroelementswithkneejointstructuressymptomsqualityoflifeandcomorbidconditionsinpeoplewithsymptomatickneeosteoarthritis AT zhuzhaohua associationsofdietarymacroelementswithkneejointstructuressymptomsqualityoflifeandcomorbidconditionsinpeoplewithsymptomatickneeosteoarthritis AT lijia associationsofdietarymacroelementswithkneejointstructuressymptomsqualityoflifeandcomorbidconditionsinpeoplewithsymptomatickneeosteoarthritis AT wangxiaoshuai associationsofdietarymacroelementswithkneejointstructuressymptomsqualityoflifeandcomorbidconditionsinpeoplewithsymptomatickneeosteoarthritis AT wlukaanitae associationsofdietarymacroelementswithkneejointstructuressymptomsqualityoflifeandcomorbidconditionsinpeoplewithsymptomatickneeosteoarthritis AT cicuttiniflavia associationsofdietarymacroelementswithkneejointstructuressymptomsqualityoflifeandcomorbidconditionsinpeoplewithsymptomatickneeosteoarthritis AT ruanguangfeng associationsofdietarymacroelementswithkneejointstructuressymptomsqualityoflifeandcomorbidconditionsinpeoplewithsymptomatickneeosteoarthritis AT dingchanghai associationsofdietarymacroelementswithkneejointstructuressymptomsqualityoflifeandcomorbidconditionsinpeoplewithsymptomatickneeosteoarthritis |