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Associations of Dietary Macroelements with Knee Joint Structures, Symptoms, Quality of Life, and Comorbid Conditions in People with Symptomatic Knee Osteoarthritis

Background: Osteoarthritis (OA), the most common joint disease in the elderly, has no cure. Macroelements are vital in human health and their relationships with OA are not clear. Clarifying the relationships between macroelements and OA may assist knee OA management. Methods: This study was a post-h...

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Autores principales: Zhang, Yan, Chen, Tianyu, Luo, Ping, Li, Shengfa, Zhu, Jianwei, Xue, Song, Cao, Peihua, Zhu, Zhaohua, Li, Jia, Wang, Xiaoshuai, Wluka, Anita E., Cicuttini, Flavia, Ruan, Guangfeng, Ding, Changhai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9460692/
https://www.ncbi.nlm.nih.gov/pubmed/36079832
http://dx.doi.org/10.3390/nu14173576
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author Zhang, Yan
Chen, Tianyu
Luo, Ping
Li, Shengfa
Zhu, Jianwei
Xue, Song
Cao, Peihua
Zhu, Zhaohua
Li, Jia
Wang, Xiaoshuai
Wluka, Anita E.
Cicuttini, Flavia
Ruan, Guangfeng
Ding, Changhai
author_facet Zhang, Yan
Chen, Tianyu
Luo, Ping
Li, Shengfa
Zhu, Jianwei
Xue, Song
Cao, Peihua
Zhu, Zhaohua
Li, Jia
Wang, Xiaoshuai
Wluka, Anita E.
Cicuttini, Flavia
Ruan, Guangfeng
Ding, Changhai
author_sort Zhang, Yan
collection PubMed
description Background: Osteoarthritis (OA), the most common joint disease in the elderly, has no cure. Macroelements are vital in human health and their relationships with OA are not clear. Clarifying the relationships between macroelements and OA may assist knee OA management. Methods: This study was a post-hoc analysis using data from a two-year randomized controlled trial among 392 participants with knee OA. Dietary macroelements, including calcium, magnesium, potassium, and phosphorus were computed-based on a semi-quantitative food frequency questionnaire at baseline. Knee joint structures (including cartilage volume, cartilage defect, bone marrow lesions, and effusion-synovitis volume), OA symptoms, quality of life, and OA comorbid conditions (including lower limb muscle strength and depressive symptoms) were assessed at baseline and month 24. Western Ontario and McMaster Universities (WOMAC) Index and depressive symptoms were assessed at baseline and months 3, 6, 12, and 24. Quality of life and lower limb muscle strength were assessed at baseline and months 6, 12, and 24. All analyses were conducted using mixed-effects models. Results: Higher dietary magnesium and potassium were associated with fewer OA symptoms, higher quality of life, greater lower limb muscle strength, and fewer depressive symptoms, but not with knee joint structures. Higher dietary calcium and phosphorus was not associated with any of the OA-related outcomes, except that dietary phosphorus was associated with greater lower limb muscle strength. Conclusions: In the longitudinal analyses, higher dietary magnesium and potassium intake are associated with fewer OA symptoms, higher quality of life, and milder comorbid conditions in patients with knee OA, suggesting dietary magnesium and potassium may have beneficial effects on OA and could be used for knee OA management.
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spelling pubmed-94606922022-09-10 Associations of Dietary Macroelements with Knee Joint Structures, Symptoms, Quality of Life, and Comorbid Conditions in People with Symptomatic Knee Osteoarthritis Zhang, Yan Chen, Tianyu Luo, Ping Li, Shengfa Zhu, Jianwei Xue, Song Cao, Peihua Zhu, Zhaohua Li, Jia Wang, Xiaoshuai Wluka, Anita E. Cicuttini, Flavia Ruan, Guangfeng Ding, Changhai Nutrients Article Background: Osteoarthritis (OA), the most common joint disease in the elderly, has no cure. Macroelements are vital in human health and their relationships with OA are not clear. Clarifying the relationships between macroelements and OA may assist knee OA management. Methods: This study was a post-hoc analysis using data from a two-year randomized controlled trial among 392 participants with knee OA. Dietary macroelements, including calcium, magnesium, potassium, and phosphorus were computed-based on a semi-quantitative food frequency questionnaire at baseline. Knee joint structures (including cartilage volume, cartilage defect, bone marrow lesions, and effusion-synovitis volume), OA symptoms, quality of life, and OA comorbid conditions (including lower limb muscle strength and depressive symptoms) were assessed at baseline and month 24. Western Ontario and McMaster Universities (WOMAC) Index and depressive symptoms were assessed at baseline and months 3, 6, 12, and 24. Quality of life and lower limb muscle strength were assessed at baseline and months 6, 12, and 24. All analyses were conducted using mixed-effects models. Results: Higher dietary magnesium and potassium were associated with fewer OA symptoms, higher quality of life, greater lower limb muscle strength, and fewer depressive symptoms, but not with knee joint structures. Higher dietary calcium and phosphorus was not associated with any of the OA-related outcomes, except that dietary phosphorus was associated with greater lower limb muscle strength. Conclusions: In the longitudinal analyses, higher dietary magnesium and potassium intake are associated with fewer OA symptoms, higher quality of life, and milder comorbid conditions in patients with knee OA, suggesting dietary magnesium and potassium may have beneficial effects on OA and could be used for knee OA management. MDPI 2022-08-30 /pmc/articles/PMC9460692/ /pubmed/36079832 http://dx.doi.org/10.3390/nu14173576 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Yan
Chen, Tianyu
Luo, Ping
Li, Shengfa
Zhu, Jianwei
Xue, Song
Cao, Peihua
Zhu, Zhaohua
Li, Jia
Wang, Xiaoshuai
Wluka, Anita E.
Cicuttini, Flavia
Ruan, Guangfeng
Ding, Changhai
Associations of Dietary Macroelements with Knee Joint Structures, Symptoms, Quality of Life, and Comorbid Conditions in People with Symptomatic Knee Osteoarthritis
title Associations of Dietary Macroelements with Knee Joint Structures, Symptoms, Quality of Life, and Comorbid Conditions in People with Symptomatic Knee Osteoarthritis
title_full Associations of Dietary Macroelements with Knee Joint Structures, Symptoms, Quality of Life, and Comorbid Conditions in People with Symptomatic Knee Osteoarthritis
title_fullStr Associations of Dietary Macroelements with Knee Joint Structures, Symptoms, Quality of Life, and Comorbid Conditions in People with Symptomatic Knee Osteoarthritis
title_full_unstemmed Associations of Dietary Macroelements with Knee Joint Structures, Symptoms, Quality of Life, and Comorbid Conditions in People with Symptomatic Knee Osteoarthritis
title_short Associations of Dietary Macroelements with Knee Joint Structures, Symptoms, Quality of Life, and Comorbid Conditions in People with Symptomatic Knee Osteoarthritis
title_sort associations of dietary macroelements with knee joint structures, symptoms, quality of life, and comorbid conditions in people with symptomatic knee osteoarthritis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9460692/
https://www.ncbi.nlm.nih.gov/pubmed/36079832
http://dx.doi.org/10.3390/nu14173576
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