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Potential Use of Agave Genus in Neuroinflammation Management

Agavaceae contains about 480 species, commonly used in the production of alcoholic beverages such as tequila and mezcal, making it a resource of economic and cultural importance. Uses of this plant rely mainly on the stem; other components such as the leaves are discarded, generating agro-industrial...

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Autores principales: Herrera-Ruiz, Maribel, Jiménez-Ferrer, Enrique, González-Cortazar, Manasés, Zamilpa, Alejandro, Cardoso-Taketa, Alexandre, Arenas-Ocampo, Martha Lucía, Jiménez-Aparicio, Antonio Ruperto, Monterrosas-Brisson, Nayeli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9460694/
https://www.ncbi.nlm.nih.gov/pubmed/36079590
http://dx.doi.org/10.3390/plants11172208
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author Herrera-Ruiz, Maribel
Jiménez-Ferrer, Enrique
González-Cortazar, Manasés
Zamilpa, Alejandro
Cardoso-Taketa, Alexandre
Arenas-Ocampo, Martha Lucía
Jiménez-Aparicio, Antonio Ruperto
Monterrosas-Brisson, Nayeli
author_facet Herrera-Ruiz, Maribel
Jiménez-Ferrer, Enrique
González-Cortazar, Manasés
Zamilpa, Alejandro
Cardoso-Taketa, Alexandre
Arenas-Ocampo, Martha Lucía
Jiménez-Aparicio, Antonio Ruperto
Monterrosas-Brisson, Nayeli
author_sort Herrera-Ruiz, Maribel
collection PubMed
description Agavaceae contains about 480 species, commonly used in the production of alcoholic beverages such as tequila and mezcal, making it a resource of economic and cultural importance. Uses of this plant rely mainly on the stem; other components such as the leaves are discarded, generating agro-industrial waste, despite being a source of bioactive and nutraceutical products. Reports show anti-inflammatory and anti-neuroinflammatory effects of these species, with flavonoids and saponins being mainly responsible. Neuroinflammation is a brain process that plays a key role in the pathogenesis of various neurodegenerative disorders and its effects contribute greatly to mortality and morbidity worldwide. This can be triggered by mechanisms such as glial reactions that lead to the release of inflammatory and oxidative molecules, causing damage to the CNS. Treatments do not cure chronic disease associated with inflammation; they only slow its progression, producing side effects that affect quality of life. Plant-based therapy is promising for treating these diseases. Pharmacological activities have been described for the Agavaceae family; however, their role in neuroinflammation has not been fully investigated, and represents an important target for study. This review synthesizes the existing literature on the biologically active compounds of Agave species that are related in some way to inflammation, which will allow us to propose a line of research with this genus on the forefront to orient experimental designs for treating neuroinflammation and associated diseases.
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spelling pubmed-94606942022-09-10 Potential Use of Agave Genus in Neuroinflammation Management Herrera-Ruiz, Maribel Jiménez-Ferrer, Enrique González-Cortazar, Manasés Zamilpa, Alejandro Cardoso-Taketa, Alexandre Arenas-Ocampo, Martha Lucía Jiménez-Aparicio, Antonio Ruperto Monterrosas-Brisson, Nayeli Plants (Basel) Review Agavaceae contains about 480 species, commonly used in the production of alcoholic beverages such as tequila and mezcal, making it a resource of economic and cultural importance. Uses of this plant rely mainly on the stem; other components such as the leaves are discarded, generating agro-industrial waste, despite being a source of bioactive and nutraceutical products. Reports show anti-inflammatory and anti-neuroinflammatory effects of these species, with flavonoids and saponins being mainly responsible. Neuroinflammation is a brain process that plays a key role in the pathogenesis of various neurodegenerative disorders and its effects contribute greatly to mortality and morbidity worldwide. This can be triggered by mechanisms such as glial reactions that lead to the release of inflammatory and oxidative molecules, causing damage to the CNS. Treatments do not cure chronic disease associated with inflammation; they only slow its progression, producing side effects that affect quality of life. Plant-based therapy is promising for treating these diseases. Pharmacological activities have been described for the Agavaceae family; however, their role in neuroinflammation has not been fully investigated, and represents an important target for study. This review synthesizes the existing literature on the biologically active compounds of Agave species that are related in some way to inflammation, which will allow us to propose a line of research with this genus on the forefront to orient experimental designs for treating neuroinflammation and associated diseases. MDPI 2022-08-25 /pmc/articles/PMC9460694/ /pubmed/36079590 http://dx.doi.org/10.3390/plants11172208 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Herrera-Ruiz, Maribel
Jiménez-Ferrer, Enrique
González-Cortazar, Manasés
Zamilpa, Alejandro
Cardoso-Taketa, Alexandre
Arenas-Ocampo, Martha Lucía
Jiménez-Aparicio, Antonio Ruperto
Monterrosas-Brisson, Nayeli
Potential Use of Agave Genus in Neuroinflammation Management
title Potential Use of Agave Genus in Neuroinflammation Management
title_full Potential Use of Agave Genus in Neuroinflammation Management
title_fullStr Potential Use of Agave Genus in Neuroinflammation Management
title_full_unstemmed Potential Use of Agave Genus in Neuroinflammation Management
title_short Potential Use of Agave Genus in Neuroinflammation Management
title_sort potential use of agave genus in neuroinflammation management
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9460694/
https://www.ncbi.nlm.nih.gov/pubmed/36079590
http://dx.doi.org/10.3390/plants11172208
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