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Chemoselective Covalent Modification of K-Ras(G12R) with a Small Molecule Electrophile
[Image: see text] KRAS mutations are one of the most common oncogenic drivers in human cancer. While small molecule inhibitors for the G12C mutant have been successfully developed, allele-specific inhibition for other KRAS hotspot mutants remains challenging. Here we report the discovery of covalent...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9460778/ https://www.ncbi.nlm.nih.gov/pubmed/36001446 http://dx.doi.org/10.1021/jacs.2c05377 |