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Study of the Association between Thiols and Oxidative Stress Markers in Children with Obesity

Obesity has reached epidemic proportions, and the World Health Organization defined childhood overweight and obesity as a noncommunicable disease that represents the most serious public health challenges of the twenty-first century. Oxidative stress, defined as an imbalance between oxidants and anti...

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Autores principales: D’Alessandro, Annamaria, Di Felice, Giovina, Manco, Melania, Pastore, Anna, Pezzi, Simona, Mariani, Michela, Fintini, Danilo, Onetti Muda, Andrea, Porzio, Ottavia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9460844/
https://www.ncbi.nlm.nih.gov/pubmed/36079892
http://dx.doi.org/10.3390/nu14173637
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author D’Alessandro, Annamaria
Di Felice, Giovina
Manco, Melania
Pastore, Anna
Pezzi, Simona
Mariani, Michela
Fintini, Danilo
Onetti Muda, Andrea
Porzio, Ottavia
author_facet D’Alessandro, Annamaria
Di Felice, Giovina
Manco, Melania
Pastore, Anna
Pezzi, Simona
Mariani, Michela
Fintini, Danilo
Onetti Muda, Andrea
Porzio, Ottavia
author_sort D’Alessandro, Annamaria
collection PubMed
description Obesity has reached epidemic proportions, and the World Health Organization defined childhood overweight and obesity as a noncommunicable disease that represents the most serious public health challenges of the twenty-first century. Oxidative stress, defined as an imbalance between oxidants and antioxidants causing an impairment of the redox signals, is linked to the development of metabolic diseases. In addition, reactive oxygen species generated during metabolic disorder could increase inflammation, causing the development of insulin resistance, diabetes, and cardiovascular disease. We analyze serum levels of cysteine (Cys), cysteinyl-glycine (Cys-Gly), homocysteine (Hcy), and glutathione (GSH), and other markers of oxidative stress, such as thiobarbituric acid reactive substances (T-BARS), 8-isoprostane, and protein carbonyl in our children with obesity. Total antioxidant status was also determined. We found lower GSH and Cys-Gly levels, and higher Hcy and oxidative stress markers levels. We also found a positive correlation between Body Mass Index (BMI), Cys, GSH, and Hcy levels, between insulin and Cys levels, and between BMI and the homeostasis model assessment-estimated insulin resistance (HOMA-IR) with 8-isoprostane levels. Finally, we found a correlation between age and GSH and Cys levels. The deficiency of GSH could be restored by dietary supplementation with GSH precursors, supplying an inexpensive approach to oppose oxidative stress, thus avoiding obesity complications.
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spelling pubmed-94608442022-09-10 Study of the Association between Thiols and Oxidative Stress Markers in Children with Obesity D’Alessandro, Annamaria Di Felice, Giovina Manco, Melania Pastore, Anna Pezzi, Simona Mariani, Michela Fintini, Danilo Onetti Muda, Andrea Porzio, Ottavia Nutrients Article Obesity has reached epidemic proportions, and the World Health Organization defined childhood overweight and obesity as a noncommunicable disease that represents the most serious public health challenges of the twenty-first century. Oxidative stress, defined as an imbalance between oxidants and antioxidants causing an impairment of the redox signals, is linked to the development of metabolic diseases. In addition, reactive oxygen species generated during metabolic disorder could increase inflammation, causing the development of insulin resistance, diabetes, and cardiovascular disease. We analyze serum levels of cysteine (Cys), cysteinyl-glycine (Cys-Gly), homocysteine (Hcy), and glutathione (GSH), and other markers of oxidative stress, such as thiobarbituric acid reactive substances (T-BARS), 8-isoprostane, and protein carbonyl in our children with obesity. Total antioxidant status was also determined. We found lower GSH and Cys-Gly levels, and higher Hcy and oxidative stress markers levels. We also found a positive correlation between Body Mass Index (BMI), Cys, GSH, and Hcy levels, between insulin and Cys levels, and between BMI and the homeostasis model assessment-estimated insulin resistance (HOMA-IR) with 8-isoprostane levels. Finally, we found a correlation between age and GSH and Cys levels. The deficiency of GSH could be restored by dietary supplementation with GSH precursors, supplying an inexpensive approach to oppose oxidative stress, thus avoiding obesity complications. MDPI 2022-09-02 /pmc/articles/PMC9460844/ /pubmed/36079892 http://dx.doi.org/10.3390/nu14173637 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
D’Alessandro, Annamaria
Di Felice, Giovina
Manco, Melania
Pastore, Anna
Pezzi, Simona
Mariani, Michela
Fintini, Danilo
Onetti Muda, Andrea
Porzio, Ottavia
Study of the Association between Thiols and Oxidative Stress Markers in Children with Obesity
title Study of the Association between Thiols and Oxidative Stress Markers in Children with Obesity
title_full Study of the Association between Thiols and Oxidative Stress Markers in Children with Obesity
title_fullStr Study of the Association between Thiols and Oxidative Stress Markers in Children with Obesity
title_full_unstemmed Study of the Association between Thiols and Oxidative Stress Markers in Children with Obesity
title_short Study of the Association between Thiols and Oxidative Stress Markers in Children with Obesity
title_sort study of the association between thiols and oxidative stress markers in children with obesity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9460844/
https://www.ncbi.nlm.nih.gov/pubmed/36079892
http://dx.doi.org/10.3390/nu14173637
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