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Alcohol Consumption and Mild Cognitive Impairment: A Mendelian Randomization Study from Rural China
Alcohol consumption has been associated with the risk of mild cognitive impairment (MCI) in observational studies. The result is inconsistent and whether the association is causal remains unknown. To examine the causal effect of alcohol consumption on MCI in rural China, this study used a cross-sect...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9460868/ https://www.ncbi.nlm.nih.gov/pubmed/36079852 http://dx.doi.org/10.3390/nu14173596 |
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author | Cui, Yi Si, Wei Zhu, Chen Zhao, Qiran |
author_facet | Cui, Yi Si, Wei Zhu, Chen Zhao, Qiran |
author_sort | Cui, Yi |
collection | PubMed |
description | Alcohol consumption has been associated with the risk of mild cognitive impairment (MCI) in observational studies. The result is inconsistent and whether the association is causal remains unknown. To examine the causal effect of alcohol consumption on MCI in rural China, this study used a cross-sectional dataset that included 1966 observations collected in rural China, of which 235 observations’ genotyping were collected. All participants accepted the MCI evaluation using Mini-Cog and were asked about the participants’ alcohol consumption behavior. The causal effect of alcohol consumption on MCI was investigated by Mendelian randomization (MR) of genetic variation in the aldehyde dehydrogenase 2 (ALDH2 rs671) gene. The risk of MCI in Chinese rural areas was 43%. Alcohol consumption was causally associated with a higher risk of MCI under MR design. Parameter estimates of drinking or not (b = 0.271, p = 0.007, 95% CI = 0.073 to 0.469), drinking frequency during the past 30 days (b = 0.016, p = 0.003, 95% CI = 0.005 to 0.027), and the weekly ethanol consumption (b = 0.132, p = 0.004, 95% CI = 0.042 to 0.223) were all positive and statistically significant at the 5% level. In conclusion, there was a high risk of MCI in rural China, and alcohol consumption was causally associated with a higher risk of MCI. |
format | Online Article Text |
id | pubmed-9460868 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94608682022-09-10 Alcohol Consumption and Mild Cognitive Impairment: A Mendelian Randomization Study from Rural China Cui, Yi Si, Wei Zhu, Chen Zhao, Qiran Nutrients Article Alcohol consumption has been associated with the risk of mild cognitive impairment (MCI) in observational studies. The result is inconsistent and whether the association is causal remains unknown. To examine the causal effect of alcohol consumption on MCI in rural China, this study used a cross-sectional dataset that included 1966 observations collected in rural China, of which 235 observations’ genotyping were collected. All participants accepted the MCI evaluation using Mini-Cog and were asked about the participants’ alcohol consumption behavior. The causal effect of alcohol consumption on MCI was investigated by Mendelian randomization (MR) of genetic variation in the aldehyde dehydrogenase 2 (ALDH2 rs671) gene. The risk of MCI in Chinese rural areas was 43%. Alcohol consumption was causally associated with a higher risk of MCI under MR design. Parameter estimates of drinking or not (b = 0.271, p = 0.007, 95% CI = 0.073 to 0.469), drinking frequency during the past 30 days (b = 0.016, p = 0.003, 95% CI = 0.005 to 0.027), and the weekly ethanol consumption (b = 0.132, p = 0.004, 95% CI = 0.042 to 0.223) were all positive and statistically significant at the 5% level. In conclusion, there was a high risk of MCI in rural China, and alcohol consumption was causally associated with a higher risk of MCI. MDPI 2022-08-31 /pmc/articles/PMC9460868/ /pubmed/36079852 http://dx.doi.org/10.3390/nu14173596 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Cui, Yi Si, Wei Zhu, Chen Zhao, Qiran Alcohol Consumption and Mild Cognitive Impairment: A Mendelian Randomization Study from Rural China |
title | Alcohol Consumption and Mild Cognitive Impairment: A Mendelian Randomization Study from Rural China |
title_full | Alcohol Consumption and Mild Cognitive Impairment: A Mendelian Randomization Study from Rural China |
title_fullStr | Alcohol Consumption and Mild Cognitive Impairment: A Mendelian Randomization Study from Rural China |
title_full_unstemmed | Alcohol Consumption and Mild Cognitive Impairment: A Mendelian Randomization Study from Rural China |
title_short | Alcohol Consumption and Mild Cognitive Impairment: A Mendelian Randomization Study from Rural China |
title_sort | alcohol consumption and mild cognitive impairment: a mendelian randomization study from rural china |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9460868/ https://www.ncbi.nlm.nih.gov/pubmed/36079852 http://dx.doi.org/10.3390/nu14173596 |
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