Receptor binding domain (RBD) antibodies contribute more to SARS-CoV-2 neutralization when target cells express high levels of ACE2

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Neutralization assays are experimental surrogates for the effectiveness of infection- or vaccine-elicited polyclonal antibodies and therapeutic monoclonal antibodies targeting SARS-CoV-2. However, the measured neutralization can depend on details of the experimental assay. Here we systematically ass...

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Detalles Bibliográficos
Autores principales: Farrell, Ariana Ghez, Dadonaite, Bernadeta, Greaney, Allison J., Eguia, Rachel, Loes, Andrea N., Franko, Nicholas M., Logue, Jennifer, Carreño, Juan Manuel, Abbad, Anass, Chu, Helen Y., Matreyek, Kenneth A., Bloom, Jesse D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9460967/
https://www.ncbi.nlm.nih.gov/pubmed/36093349
http://dx.doi.org/10.1101/2022.08.29.505713
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