Impact of N6-methyladenosine (m(6)A) modification on immunity

N6-methyl-adenosine (m(6)A) is the most prevalent modification on mRNAs and long noncoding RNAs (lnRNAs) in higher eukaryotes. Modulation of m(6)A relies on m(6)A writers, erasers and readers. m(6)A modification contributes to diverse fundamental biological functions at the molecular, cellular, and...

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Detalles Bibliográficos
Autores principales: Elsabbagh, Raghda A., Rady, Mona, Watzl, Carsten, Abou-Aisha, Khaled, Gad, Mohamed Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9461097/
https://www.ncbi.nlm.nih.gov/pubmed/36085064
http://dx.doi.org/10.1186/s12964-022-00939-8
Descripción
Sumario:N6-methyl-adenosine (m(6)A) is the most prevalent modification on mRNAs and long noncoding RNAs (lnRNAs) in higher eukaryotes. Modulation of m(6)A relies on m(6)A writers, erasers and readers. m(6)A modification contributes to diverse fundamental biological functions at the molecular, cellular, and physiological levels. The dysregulation of m(6)A modification has been implicated in various human diseases. Thus, m(6)A modification has now become a research hotspot for its potential therapeutic applications in the treatment of various cancers and diseases. The immune system is essential to provide defense against infections and cancers. This review summarizes the current knowledge about the roles of m(6)A in regulating immune cell functions and immune responses. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-022-00939-8.

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