Impact of N6-methyladenosine (m(6)A) modification on immunity

N6-methyl-adenosine (m(6)A) is the most prevalent modification on mRNAs and long noncoding RNAs (lnRNAs) in higher eukaryotes. Modulation of m(6)A relies on m(6)A writers, erasers and readers. m(6)A modification contributes to diverse fundamental biological functions at the molecular, cellular, and...

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Autores principales: Elsabbagh, Raghda A., Rady, Mona, Watzl, Carsten, Abou-Aisha, Khaled, Gad, Mohamed Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9461097/
https://www.ncbi.nlm.nih.gov/pubmed/36085064
http://dx.doi.org/10.1186/s12964-022-00939-8
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author Elsabbagh, Raghda A.
Rady, Mona
Watzl, Carsten
Abou-Aisha, Khaled
Gad, Mohamed Z.
author_facet Elsabbagh, Raghda A.
Rady, Mona
Watzl, Carsten
Abou-Aisha, Khaled
Gad, Mohamed Z.
author_sort Elsabbagh, Raghda A.
collection PubMed
description N6-methyl-adenosine (m(6)A) is the most prevalent modification on mRNAs and long noncoding RNAs (lnRNAs) in higher eukaryotes. Modulation of m(6)A relies on m(6)A writers, erasers and readers. m(6)A modification contributes to diverse fundamental biological functions at the molecular, cellular, and physiological levels. The dysregulation of m(6)A modification has been implicated in various human diseases. Thus, m(6)A modification has now become a research hotspot for its potential therapeutic applications in the treatment of various cancers and diseases. The immune system is essential to provide defense against infections and cancers. This review summarizes the current knowledge about the roles of m(6)A in regulating immune cell functions and immune responses. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-022-00939-8.
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spelling pubmed-94610972022-09-10 Impact of N6-methyladenosine (m(6)A) modification on immunity Elsabbagh, Raghda A. Rady, Mona Watzl, Carsten Abou-Aisha, Khaled Gad, Mohamed Z. Cell Commun Signal Review N6-methyl-adenosine (m(6)A) is the most prevalent modification on mRNAs and long noncoding RNAs (lnRNAs) in higher eukaryotes. Modulation of m(6)A relies on m(6)A writers, erasers and readers. m(6)A modification contributes to diverse fundamental biological functions at the molecular, cellular, and physiological levels. The dysregulation of m(6)A modification has been implicated in various human diseases. Thus, m(6)A modification has now become a research hotspot for its potential therapeutic applications in the treatment of various cancers and diseases. The immune system is essential to provide defense against infections and cancers. This review summarizes the current knowledge about the roles of m(6)A in regulating immune cell functions and immune responses. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-022-00939-8. BioMed Central 2022-09-09 /pmc/articles/PMC9461097/ /pubmed/36085064 http://dx.doi.org/10.1186/s12964-022-00939-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Elsabbagh, Raghda A.
Rady, Mona
Watzl, Carsten
Abou-Aisha, Khaled
Gad, Mohamed Z.
Impact of N6-methyladenosine (m(6)A) modification on immunity
title Impact of N6-methyladenosine (m(6)A) modification on immunity
title_full Impact of N6-methyladenosine (m(6)A) modification on immunity
title_fullStr Impact of N6-methyladenosine (m(6)A) modification on immunity
title_full_unstemmed Impact of N6-methyladenosine (m(6)A) modification on immunity
title_short Impact of N6-methyladenosine (m(6)A) modification on immunity
title_sort impact of n6-methyladenosine (m(6)a) modification on immunity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9461097/
https://www.ncbi.nlm.nih.gov/pubmed/36085064
http://dx.doi.org/10.1186/s12964-022-00939-8
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