Dissection of transcriptome dysregulation and immune characterization in women with germline BRCA1 mutation at single-cell resolution

BACKGROUND: High-grade serous carcinoma (HGSC) is the most frequent and lethal type of ovarian cancer. It has been proposed that tubal secretory cells are the origin of ovarian HGSC in women with familial BRCA1/2 mutations. However, the molecular changes underlying malignant transformation remain un...

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Detalles Bibliográficos
Autores principales: Yu, Xuexin, Lin, Wanrun, Spirtos, Alexandra, Wang, Yan, Chen, Hao, Ye, Jianfeng, Parker, Jessica, Liu, Ci Ci, Wang, Yiying, Quinn, Gabriella, Zhou, Feng, Chambers, Setsuko K., Lewis, Cheryl, Lea, Jayanthi, Li, Bo, Zheng, Wenxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9461201/
https://www.ncbi.nlm.nih.gov/pubmed/36076202
http://dx.doi.org/10.1186/s12916-022-02489-9

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