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Serum vitamin D levels and COVID-19 during pregnancy: A systematic review and meta-analysis
BACKGROUND: Serum vitamin D levels are reported to be associated with the risk of incidence and severity of COVID-19 in the general population. During pregnancy, immune system alterations in line with changes in vitamin D metabolism may affect the course of COVID-19. Thus, we aimed to systematically...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9461277/ https://www.ncbi.nlm.nih.gov/pubmed/36184196 http://dx.doi.org/10.1016/j.clnesp.2022.09.008 |
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author | Mazaheri-Tehrani, Sadegh Mirzapour, Mohammad Hossein Yazdi, Maryam Fakhrolmobasheri, Mohammad Abhari, Amir Parsa |
author_facet | Mazaheri-Tehrani, Sadegh Mirzapour, Mohammad Hossein Yazdi, Maryam Fakhrolmobasheri, Mohammad Abhari, Amir Parsa |
author_sort | Mazaheri-Tehrani, Sadegh |
collection | PubMed |
description | BACKGROUND: Serum vitamin D levels are reported to be associated with the risk of incidence and severity of COVID-19 in the general population. During pregnancy, immune system alterations in line with changes in vitamin D metabolism may affect the course of COVID-19. Thus, we aimed to systematically review the association between vitamin D, pregnancy, and COVID-19. METHODS: A systematic literature search was conducted in PubMed, Scopus, Web of Science, Embase, and Google Scholar until the end of May 2022. Mean differences (MD) with 95% CI were used as desired effect sizes to assess the association of serum vitamin D levels with the risk of incidence and severity of COVID-19 in pregnant women. RESULTS: Among 259 records, 7 and 6 studies were included in the systematic review and meta-analysis, respectively. All included studies had acceptable quality. Our results demonstrated an insignificant difference between infected women and non-infected controls (MD = -2.55 ng/ml, 95% CI: −6.85 – 1.74). But serum vitamin D levels in severe/moderate cases compared to mild ones (MD = −2.71 ng/ml, 95% CI: −4.18 to −1.24) are significantly lower. CONCLUSION: Based on the current evidence, serum vitamin D level does not associate with the risk of SARS-CoV-2 infection among pregnant women, but we find a significant association with the severity of the disease. These findings may be helpful in similar conditions and future studies to better understand the complex immune alterations during pregnancy. |
format | Online Article Text |
id | pubmed-9461277 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94612772022-09-10 Serum vitamin D levels and COVID-19 during pregnancy: A systematic review and meta-analysis Mazaheri-Tehrani, Sadegh Mirzapour, Mohammad Hossein Yazdi, Maryam Fakhrolmobasheri, Mohammad Abhari, Amir Parsa Clin Nutr ESPEN Meta-Analysis BACKGROUND: Serum vitamin D levels are reported to be associated with the risk of incidence and severity of COVID-19 in the general population. During pregnancy, immune system alterations in line with changes in vitamin D metabolism may affect the course of COVID-19. Thus, we aimed to systematically review the association between vitamin D, pregnancy, and COVID-19. METHODS: A systematic literature search was conducted in PubMed, Scopus, Web of Science, Embase, and Google Scholar until the end of May 2022. Mean differences (MD) with 95% CI were used as desired effect sizes to assess the association of serum vitamin D levels with the risk of incidence and severity of COVID-19 in pregnant women. RESULTS: Among 259 records, 7 and 6 studies were included in the systematic review and meta-analysis, respectively. All included studies had acceptable quality. Our results demonstrated an insignificant difference between infected women and non-infected controls (MD = -2.55 ng/ml, 95% CI: −6.85 – 1.74). But serum vitamin D levels in severe/moderate cases compared to mild ones (MD = −2.71 ng/ml, 95% CI: −4.18 to −1.24) are significantly lower. CONCLUSION: Based on the current evidence, serum vitamin D level does not associate with the risk of SARS-CoV-2 infection among pregnant women, but we find a significant association with the severity of the disease. These findings may be helpful in similar conditions and future studies to better understand the complex immune alterations during pregnancy. European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. 2022-10 2022-09-09 /pmc/articles/PMC9461277/ /pubmed/36184196 http://dx.doi.org/10.1016/j.clnesp.2022.09.008 Text en © 2022 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Meta-Analysis Mazaheri-Tehrani, Sadegh Mirzapour, Mohammad Hossein Yazdi, Maryam Fakhrolmobasheri, Mohammad Abhari, Amir Parsa Serum vitamin D levels and COVID-19 during pregnancy: A systematic review and meta-analysis |
title | Serum vitamin D levels and COVID-19 during pregnancy: A systematic review and meta-analysis |
title_full | Serum vitamin D levels and COVID-19 during pregnancy: A systematic review and meta-analysis |
title_fullStr | Serum vitamin D levels and COVID-19 during pregnancy: A systematic review and meta-analysis |
title_full_unstemmed | Serum vitamin D levels and COVID-19 during pregnancy: A systematic review and meta-analysis |
title_short | Serum vitamin D levels and COVID-19 during pregnancy: A systematic review and meta-analysis |
title_sort | serum vitamin d levels and covid-19 during pregnancy: a systematic review and meta-analysis |
topic | Meta-Analysis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9461277/ https://www.ncbi.nlm.nih.gov/pubmed/36184196 http://dx.doi.org/10.1016/j.clnesp.2022.09.008 |
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