Cargando…

COVID-19 diverse outcomes: Aggravated reinfection, type I interferons and antibodies

SARS-CoV-2 infection intrigued medicine with diverse outcomes ranging from asymptomatic to severe acute respiratory syndrome (SARS) and death. After more than two years of pandemic, reports of reinfection concern researchers and physicists. Here, we will discuss potential mechanisms that can explain...

Descripción completa

Detalles Bibliográficos
Autores principales: Costa Silva, Rafael Cardoso Maciel, Bandeira-Melo, Christianne, Paula Neto, Heitor Afonso, Vale, André Macedo, Travassos, Leonardo Holanda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9461281/
https://www.ncbi.nlm.nih.gov/pubmed/36105250
http://dx.doi.org/10.1016/j.mehy.2022.110943
_version_ 1784786942677745664
author Costa Silva, Rafael Cardoso Maciel
Bandeira-Melo, Christianne
Paula Neto, Heitor Afonso
Vale, André Macedo
Travassos, Leonardo Holanda
author_facet Costa Silva, Rafael Cardoso Maciel
Bandeira-Melo, Christianne
Paula Neto, Heitor Afonso
Vale, André Macedo
Travassos, Leonardo Holanda
author_sort Costa Silva, Rafael Cardoso Maciel
collection PubMed
description SARS-CoV-2 infection intrigued medicine with diverse outcomes ranging from asymptomatic to severe acute respiratory syndrome (SARS) and death. After more than two years of pandemic, reports of reinfection concern researchers and physicists. Here, we will discuss potential mechanisms that can explain reinfections, including the aggravated ones. The major topics of this hypothesis paper are the disbalance between interferon and antibodies responses, HLA heterogeneity among the affected population, and increased proportion of cytotoxic CD4+ T cells polarization in relation to T follicular cells (Tfh) subtypes. These features affect antibody levels and hamper the humoral immunity necessary to prevent or minimize the viral burden in the case of reinfections.
format Online
Article
Text
id pubmed-9461281
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Elsevier Ltd.
record_format MEDLINE/PubMed
spelling pubmed-94612812022-09-10 COVID-19 diverse outcomes: Aggravated reinfection, type I interferons and antibodies Costa Silva, Rafael Cardoso Maciel Bandeira-Melo, Christianne Paula Neto, Heitor Afonso Vale, André Macedo Travassos, Leonardo Holanda Med Hypotheses Article SARS-CoV-2 infection intrigued medicine with diverse outcomes ranging from asymptomatic to severe acute respiratory syndrome (SARS) and death. After more than two years of pandemic, reports of reinfection concern researchers and physicists. Here, we will discuss potential mechanisms that can explain reinfections, including the aggravated ones. The major topics of this hypothesis paper are the disbalance between interferon and antibodies responses, HLA heterogeneity among the affected population, and increased proportion of cytotoxic CD4+ T cells polarization in relation to T follicular cells (Tfh) subtypes. These features affect antibody levels and hamper the humoral immunity necessary to prevent or minimize the viral burden in the case of reinfections. Elsevier Ltd. 2022-10 2022-09-09 /pmc/articles/PMC9461281/ /pubmed/36105250 http://dx.doi.org/10.1016/j.mehy.2022.110943 Text en © 2022 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Costa Silva, Rafael Cardoso Maciel
Bandeira-Melo, Christianne
Paula Neto, Heitor Afonso
Vale, André Macedo
Travassos, Leonardo Holanda
COVID-19 diverse outcomes: Aggravated reinfection, type I interferons and antibodies
title COVID-19 diverse outcomes: Aggravated reinfection, type I interferons and antibodies
title_full COVID-19 diverse outcomes: Aggravated reinfection, type I interferons and antibodies
title_fullStr COVID-19 diverse outcomes: Aggravated reinfection, type I interferons and antibodies
title_full_unstemmed COVID-19 diverse outcomes: Aggravated reinfection, type I interferons and antibodies
title_short COVID-19 diverse outcomes: Aggravated reinfection, type I interferons and antibodies
title_sort covid-19 diverse outcomes: aggravated reinfection, type i interferons and antibodies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9461281/
https://www.ncbi.nlm.nih.gov/pubmed/36105250
http://dx.doi.org/10.1016/j.mehy.2022.110943
work_keys_str_mv AT costasilvarafaelcardosomaciel covid19diverseoutcomesaggravatedreinfectiontypeiinterferonsandantibodies
AT bandeiramelochristianne covid19diverseoutcomesaggravatedreinfectiontypeiinterferonsandantibodies
AT paulanetoheitorafonso covid19diverseoutcomesaggravatedreinfectiontypeiinterferonsandantibodies
AT valeandremacedo covid19diverseoutcomesaggravatedreinfectiontypeiinterferonsandantibodies
AT travassosleonardoholanda covid19diverseoutcomesaggravatedreinfectiontypeiinterferonsandantibodies