Arsenal of nanobodies shows broad-spectrum neutralization against SARS-CoV-2 variants of concern in vitro and in vivo in hamster models

Nanobodies offer several potential advantages over mAbs for the control of SARS-CoV-2. Their ability to access cryptic epitopes conserved across SARS-CoV-2 variants of concern (VoCs) and feasibility to engineer modular, multimeric designs, make these antibody fragments ideal candidates for developin...

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Detalles Bibliográficos
Autores principales: Rossotti, Martin A., van Faassen, Henk, Tran, Anh T., Sheff, Joey, Sandhu, Jagdeep K., Duque, Diana, Hewitt, Melissa, Wen, Xiaoxue, Bavananthasivam, Jegarubee, Beitari, Saina, Matte, Kevin, Laroche, Geneviève, Giguère, Patrick M., Gervais, Christian, Stuible, Matthew, Guimond, Julie, Perret, Sylvie, Hussack, Greg, Langlois, Marc-André, Durocher, Yves, Tanha, Jamshid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9461429/
https://www.ncbi.nlm.nih.gov/pubmed/36085335
http://dx.doi.org/10.1038/s42003-022-03866-z

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