A novel methylated cation channel TRPM4 inhibited colorectal cancer metastasis through Ca(2+)/Calpain-mediated proteolysis of FAK and suppression of PI3K/Akt/mTOR signaling pathway

Colorectal cancer (CRC) is an aggressive malignancy with poor prognosis. It is imperative to elucidate the potential molecular mechanisms that regulate CRC cell aggressiveness. In present study, the transient receptor potential melastatin 4 (TRPM4), a calcium-activated nonselective cation channel, i...

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Detalles Bibliográficos
Autores principales: Wang, Chan, Chen, Jiaxin, Kuang, Yeye, Cheng, Xiaoqing, Deng, Min, Jiang, Zhinong, Hu, Xiaotong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9461655/
https://www.ncbi.nlm.nih.gov/pubmed/36147460
http://dx.doi.org/10.7150/ijbs.70504

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