Downregulation of PPARα mediates FABP1 expression, contributing to IgA nephropathy by stimulating ferroptosis in human mesangial cells

Immunoglobulin A nephropathy (IgAN) is the commonest primary glomerulonephritis, and a major cause of end-stage renal disease; however, its pathogenesis requires elucidation. Here, a hub gene, FABP1, and signaling pathway, PPARα, were selected as key in IgAN pathogenesis by combined weighted gene co...

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Detalles Bibliográficos
Autores principales: Wu, Jingkui, Shao, Xinghua, Shen, Jianxiao, Lin, Qisheng, Zhu, Xuying, Li, Shu, Li, Jialin, Zhou, Wenyan, Qi, Chaojun, Ni, Zhaohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9461665/
https://www.ncbi.nlm.nih.gov/pubmed/36147466
http://dx.doi.org/10.7150/ijbs.74675

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