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Renal Dysfunction in Patients with Left Ventricular Assist Device
Late-stage heart failure and renal dysfunction are often seen in conjunction. Cardiorenal syndrome (CRS) describes the complex interaction between the two disease states. Early literature described the pathophysiology of CRS as related only to reduced cardiac output and decreased renal perfusion. Re...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Houston Methodist DeBakey Heart & Vascular Center
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9461688/ https://www.ncbi.nlm.nih.gov/pubmed/36132586 http://dx.doi.org/10.14797/mdcvj.1146 |
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author | El Nihum, Lamees I. Manian, Nina Arunachalam, Priya Al Abri, Qasim Guha, Ashrith |
author_facet | El Nihum, Lamees I. Manian, Nina Arunachalam, Priya Al Abri, Qasim Guha, Ashrith |
author_sort | El Nihum, Lamees I. |
collection | PubMed |
description | Late-stage heart failure and renal dysfunction are often seen in conjunction. Cardiorenal syndrome (CRS) describes the complex interaction between the two disease states. Early literature described the pathophysiology of CRS as related only to reduced cardiac output and decreased renal perfusion. Recent literature suggests a more multifaceted mechanism. Left ventricular assist devices (LVAD), used as bridge-to-transplant and destination therapy in patients with heart failure, impact not only cardiac function but also renal function, especially in those patients with preoperative renal dysfunction. The mechanism by which LVAD implantation affects renal function is complex and understated in early literature. In this review, we discuss the pathogenesis of CRS, the impact of preoperative renal dysfunction in patients undergoing LVAD implantation, and the effect of LVAD implantation on postoperative renal function. |
format | Online Article Text |
id | pubmed-9461688 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Houston Methodist DeBakey Heart & Vascular Center |
record_format | MEDLINE/PubMed |
spelling | pubmed-94616882022-09-20 Renal Dysfunction in Patients with Left Ventricular Assist Device El Nihum, Lamees I. Manian, Nina Arunachalam, Priya Al Abri, Qasim Guha, Ashrith Methodist Debakey Cardiovasc J Review Late-stage heart failure and renal dysfunction are often seen in conjunction. Cardiorenal syndrome (CRS) describes the complex interaction between the two disease states. Early literature described the pathophysiology of CRS as related only to reduced cardiac output and decreased renal perfusion. Recent literature suggests a more multifaceted mechanism. Left ventricular assist devices (LVAD), used as bridge-to-transplant and destination therapy in patients with heart failure, impact not only cardiac function but also renal function, especially in those patients with preoperative renal dysfunction. The mechanism by which LVAD implantation affects renal function is complex and understated in early literature. In this review, we discuss the pathogenesis of CRS, the impact of preoperative renal dysfunction in patients undergoing LVAD implantation, and the effect of LVAD implantation on postoperative renal function. Houston Methodist DeBakey Heart & Vascular Center 2022-09-06 /pmc/articles/PMC9461688/ /pubmed/36132586 http://dx.doi.org/10.14797/mdcvj.1146 Text en Copyright: © 2022 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC-BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Review El Nihum, Lamees I. Manian, Nina Arunachalam, Priya Al Abri, Qasim Guha, Ashrith Renal Dysfunction in Patients with Left Ventricular Assist Device |
title | Renal Dysfunction in Patients with Left Ventricular Assist Device |
title_full | Renal Dysfunction in Patients with Left Ventricular Assist Device |
title_fullStr | Renal Dysfunction in Patients with Left Ventricular Assist Device |
title_full_unstemmed | Renal Dysfunction in Patients with Left Ventricular Assist Device |
title_short | Renal Dysfunction in Patients with Left Ventricular Assist Device |
title_sort | renal dysfunction in patients with left ventricular assist device |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9461688/ https://www.ncbi.nlm.nih.gov/pubmed/36132586 http://dx.doi.org/10.14797/mdcvj.1146 |
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