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Hypertension Management in Patients with Chronic Kidney Disease
Hypertension and chronic kidney disease are closely linked. Patients with chronic kidney disease have hypertension almost universally and uncontrolled hypertension accelerates the decline in kidney function. The pathophysiology of hypertension in chronic kidney disease is complex, but is largely rel...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Houston Methodist DeBakey Heart & Vascular Center
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9461694/ https://www.ncbi.nlm.nih.gov/pubmed/36132579 http://dx.doi.org/10.14797/mdcvj.1119 |
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author | Hebert, Sean A. Ibrahim, Hassan N. |
author_facet | Hebert, Sean A. Ibrahim, Hassan N. |
author_sort | Hebert, Sean A. |
collection | PubMed |
description | Hypertension and chronic kidney disease are closely linked. Patients with chronic kidney disease have hypertension almost universally and uncontrolled hypertension accelerates the decline in kidney function. The pathophysiology of hypertension in chronic kidney disease is complex, but is largely related to reduced nephron mass, sympathetic nervous system overactivation, involvement of the renin-angiotensin-aldosterone system, and generalized endothelial dysfunction. Consensus guidelines for blood pressure targets have adopted a blood pressure <120/80 mm Hg in native chronic kidney disease and <130/80 mm Hg in kidney transplant recipients. Guidelines also strongly advocate for renin-angiotensin-aldosterone system blockade as the first-line therapy. |
format | Online Article Text |
id | pubmed-9461694 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Houston Methodist DeBakey Heart & Vascular Center |
record_format | MEDLINE/PubMed |
spelling | pubmed-94616942022-09-20 Hypertension Management in Patients with Chronic Kidney Disease Hebert, Sean A. Ibrahim, Hassan N. Methodist Debakey Cardiovasc J Review Hypertension and chronic kidney disease are closely linked. Patients with chronic kidney disease have hypertension almost universally and uncontrolled hypertension accelerates the decline in kidney function. The pathophysiology of hypertension in chronic kidney disease is complex, but is largely related to reduced nephron mass, sympathetic nervous system overactivation, involvement of the renin-angiotensin-aldosterone system, and generalized endothelial dysfunction. Consensus guidelines for blood pressure targets have adopted a blood pressure <120/80 mm Hg in native chronic kidney disease and <130/80 mm Hg in kidney transplant recipients. Guidelines also strongly advocate for renin-angiotensin-aldosterone system blockade as the first-line therapy. Houston Methodist DeBakey Heart & Vascular Center 2022-09-06 /pmc/articles/PMC9461694/ /pubmed/36132579 http://dx.doi.org/10.14797/mdcvj.1119 Text en Copyright: © 2022 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC-BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Review Hebert, Sean A. Ibrahim, Hassan N. Hypertension Management in Patients with Chronic Kidney Disease |
title | Hypertension Management in Patients with Chronic Kidney Disease |
title_full | Hypertension Management in Patients with Chronic Kidney Disease |
title_fullStr | Hypertension Management in Patients with Chronic Kidney Disease |
title_full_unstemmed | Hypertension Management in Patients with Chronic Kidney Disease |
title_short | Hypertension Management in Patients with Chronic Kidney Disease |
title_sort | hypertension management in patients with chronic kidney disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9461694/ https://www.ncbi.nlm.nih.gov/pubmed/36132579 http://dx.doi.org/10.14797/mdcvj.1119 |
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