Pediatric glioblastoma cells are sensitive to drugs that inhibit eIF2α dephosphorylation and its phosphomimetic S51D variant

We found that pediatric glioblastoma (PED-GBM) cell lines from diffuse intrinsic pontine glioma (DIPG) carrying the H3K27M mutation or from diffuse hemispheric glioma expressing the H3G34R mutation are sensitive to the combination of vorinostat (a histone deacetylase inhibitor) and PARP-1 inhibitors...

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Detalles Bibliográficos
Autores principales: Eytan, Karin, Versano, Ziv, Oren, Roni, Jacob-Hirsch, Jasmine, Leitner, Moshe, Harmelin, Alon, Rechavi, Gideon, Toren, Amos, Paglin, Shoshana, Yalon, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462064/
https://www.ncbi.nlm.nih.gov/pubmed/36091130
http://dx.doi.org/10.3389/fonc.2022.959133

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