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Ethyl 10α-hydroxy-4,9-dimethyl-14-oxo-3,8,15-trioxatetracyclo[10.3.0.0(2,4).0(7,9)]pentadecane-13-spiro-5′-pyrazole-3′-carboxylate
The ten-membered ring in the title molecule, C(25)H(29)ClN(2)O(7), adopts an approximate chair–chair conformation, whereas the five-membered furan and pyrazole rings display envelope conformations. The mean plane of the furan ring is almost perpendicular to that of the pyrazole ring, as indicated b...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462250/ https://www.ncbi.nlm.nih.gov/pubmed/36339783 http://dx.doi.org/10.1107/S2414314620009451 |
Sumario: | The ten-membered ring in the title molecule, C(25)H(29)ClN(2)O(7), adopts an approximate chair–chair conformation, whereas the five-membered furan and pyrazole rings display envelope conformations. The mean plane of the furan ring is almost perpendicular to that of the pyrazole ring, as indicated by the dihedral angle between them of 86.45 (9)°. The pyrazole ring is slightly inclined to the plane of the attached phenyl ring, subtending a dihedral angle of 16.88 (8)°. The conformation of the molecule is stabilized by six intramolecular hydrogen bonds and crystal cohesion is ensured by five C—H⋯O hydrogen bonds, in addition to C—H⋯π interactions. [Image: see text] |
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