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A comparative study of amplitude of low-frequence fluctuation of resting-state fMRI between the younger and older treatment-resistant depression in adults

BACKGROUND: Treatment-resistant depression (TRD) may have different physiopathological neuromechanism in different age groups. This study used the amplitude of low frequency fluctuations (ALFF) to initially compare abnormalities in local functional brain activity in younger and older patients with T...

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Autores principales: Sun, Jifei, Guo, Chunlei, Ma, Yue, Du, Zhongming, Wang, Zhi, Luo, Yi, Chen, Limei, Gao, Deqiang, Li, Xiaojiao, Xu, Ke, Hong, Yang, Yu, Xue, Xiao, Xue, Fang, Jiliang, Liu, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462398/
https://www.ncbi.nlm.nih.gov/pubmed/36090288
http://dx.doi.org/10.3389/fnins.2022.949698
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author Sun, Jifei
Guo, Chunlei
Ma, Yue
Du, Zhongming
Wang, Zhi
Luo, Yi
Chen, Limei
Gao, Deqiang
Li, Xiaojiao
Xu, Ke
Hong, Yang
Yu, Xue
Xiao, Xue
Fang, Jiliang
Liu, Yong
author_facet Sun, Jifei
Guo, Chunlei
Ma, Yue
Du, Zhongming
Wang, Zhi
Luo, Yi
Chen, Limei
Gao, Deqiang
Li, Xiaojiao
Xu, Ke
Hong, Yang
Yu, Xue
Xiao, Xue
Fang, Jiliang
Liu, Yong
author_sort Sun, Jifei
collection PubMed
description BACKGROUND: Treatment-resistant depression (TRD) may have different physiopathological neuromechanism in different age groups. This study used the amplitude of low frequency fluctuations (ALFF) to initially compare abnormalities in local functional brain activity in younger and older patients with TRD. MATERIALS AND METHODS: A total of 21 older TRD patients, 19 younger TRD, 19 older healthy controls (HCs), and 19 younger HCs underwent resting-state functional MRI scans, and the images were analyzed using the ALFF and further analyzed for correlation between abnormal brain regions and clinical symptoms in TRD patients of different age groups. RESULTS: Compared with the older TRD, the younger TRD group had increased ALFF in the left middle frontal gyrus and decreased ALFF in the left caudate nucleus. Compared with the matched HC group, ALFF was increased in the right middle temporal gyrus and left pallidum in the older TRD group, whereas no significant differences were found in the younger TRD group. In addition, ALFF values in the left middle frontal gyrus in the younger TRD group and in the right middle temporal gyrus in the older TRD were both positively correlated with the 17-item Hamilton Rating Scale for Depression score. CONCLUSION: Different neuropathological mechanisms may exist in TRD patients of different ages, especially in the left middle frontal gyrus and left caudate nucleus. This study is beneficial in providing potential key targets for the clinical management of TRD patients of different ages.
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spelling pubmed-94623982022-09-10 A comparative study of amplitude of low-frequence fluctuation of resting-state fMRI between the younger and older treatment-resistant depression in adults Sun, Jifei Guo, Chunlei Ma, Yue Du, Zhongming Wang, Zhi Luo, Yi Chen, Limei Gao, Deqiang Li, Xiaojiao Xu, Ke Hong, Yang Yu, Xue Xiao, Xue Fang, Jiliang Liu, Yong Front Neurosci Neuroscience BACKGROUND: Treatment-resistant depression (TRD) may have different physiopathological neuromechanism in different age groups. This study used the amplitude of low frequency fluctuations (ALFF) to initially compare abnormalities in local functional brain activity in younger and older patients with TRD. MATERIALS AND METHODS: A total of 21 older TRD patients, 19 younger TRD, 19 older healthy controls (HCs), and 19 younger HCs underwent resting-state functional MRI scans, and the images were analyzed using the ALFF and further analyzed for correlation between abnormal brain regions and clinical symptoms in TRD patients of different age groups. RESULTS: Compared with the older TRD, the younger TRD group had increased ALFF in the left middle frontal gyrus and decreased ALFF in the left caudate nucleus. Compared with the matched HC group, ALFF was increased in the right middle temporal gyrus and left pallidum in the older TRD group, whereas no significant differences were found in the younger TRD group. In addition, ALFF values in the left middle frontal gyrus in the younger TRD group and in the right middle temporal gyrus in the older TRD were both positively correlated with the 17-item Hamilton Rating Scale for Depression score. CONCLUSION: Different neuropathological mechanisms may exist in TRD patients of different ages, especially in the left middle frontal gyrus and left caudate nucleus. This study is beneficial in providing potential key targets for the clinical management of TRD patients of different ages. Frontiers Media S.A. 2022-08-25 /pmc/articles/PMC9462398/ /pubmed/36090288 http://dx.doi.org/10.3389/fnins.2022.949698 Text en Copyright © 2022 Sun, Guo, Ma, Du, Wang, Luo, Chen, Gao, Li, Xu, Hong, Yu, Xiao, Fang and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Sun, Jifei
Guo, Chunlei
Ma, Yue
Du, Zhongming
Wang, Zhi
Luo, Yi
Chen, Limei
Gao, Deqiang
Li, Xiaojiao
Xu, Ke
Hong, Yang
Yu, Xue
Xiao, Xue
Fang, Jiliang
Liu, Yong
A comparative study of amplitude of low-frequence fluctuation of resting-state fMRI between the younger and older treatment-resistant depression in adults
title A comparative study of amplitude of low-frequence fluctuation of resting-state fMRI between the younger and older treatment-resistant depression in adults
title_full A comparative study of amplitude of low-frequence fluctuation of resting-state fMRI between the younger and older treatment-resistant depression in adults
title_fullStr A comparative study of amplitude of low-frequence fluctuation of resting-state fMRI between the younger and older treatment-resistant depression in adults
title_full_unstemmed A comparative study of amplitude of low-frequence fluctuation of resting-state fMRI between the younger and older treatment-resistant depression in adults
title_short A comparative study of amplitude of low-frequence fluctuation of resting-state fMRI between the younger and older treatment-resistant depression in adults
title_sort comparative study of amplitude of low-frequence fluctuation of resting-state fmri between the younger and older treatment-resistant depression in adults
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462398/
https://www.ncbi.nlm.nih.gov/pubmed/36090288
http://dx.doi.org/10.3389/fnins.2022.949698
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