An in vivo model of glioblastoma radiation resistance identifies long noncoding RNAs and targetable kinases

Key molecular regulators of acquired radiation resistance in recurrent glioblastoma (GBM) are largely unknown, with a dearth of accurate preclinical models. To address this, we generated 8 GBM patient-derived xenograft (PDX) models of acquired radiation therapy–selected (RTS) resistance compared wit...

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Detalles Bibliográficos
Autores principales: Stackhouse, Christian T., Anderson, Joshua C., Yue, Zongliang, Nguyen, Thanh, Eustace, Nicholas J., Langford, Catherine P., Wang, Jelai, Rowland, James R., Xing, Chuan, Mikhail, Fady M., Cui, Xiangqin, Alrefai, Hasan, Bash, Ryan E., Lee, Kevin J., Yang, Eddy S., Hjelmeland, Anita B., Miller, C. Ryan, Chen, Jake Y., Gillespie, G. Yancey, Willey, Christopher D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462495/
https://www.ncbi.nlm.nih.gov/pubmed/35852875
http://dx.doi.org/10.1172/jci.insight.148717

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