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SEMA7A(R148W) mutation promotes lipid accumulation and NAFLD progression via increased localization on the hepatocyte surface

Genetic polymorphisms are associated with the development of nonalcoholic fatty liver disease (NAFLD). Semaphorin7a (Sema7a) deficiency in mouse peritoneal macrophages reduces fatty acid (FA) oxidation. Here, we identified 17 individuals with SEMA7A heterozygous mutations in 470 patients with biopsy...

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Detalles Bibliográficos
Autores principales: Zhao, Nan, Zhang, Xiaoxun, Ding, Jingjing, Pan, Qiong, Zheng, Ming-Hua, Liu, Wen-Yue, Luo, Gang, Qu, Jiaquan, Li, Mingqiao, Li, Ling, Cheng, Ying, Peng, Ying, Xie, Qiaoling, Wei, Qinglin, Li, Qiao, Zou, Lingyun, Ouyang, Xinshou, Cai, Shi-Ying, Boyer, James L., Chai, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462498/
https://www.ncbi.nlm.nih.gov/pubmed/35938531
http://dx.doi.org/10.1172/jci.insight.154113

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