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Human T-bet(+) B cell development is associated with BTK activity and suppressed by evobrutinib
Recent clinical trials have shown promising results for the next-generation Bruton’s tyrosine kinase (BTK) inhibitor evobrutinib in the treatment of multiple sclerosis (MS). BTK has a central role in signaling pathways that govern the development of B cells. Whether and how BTK activity shapes B cel...
Autores principales: | Rijvers, Liza, van Langelaar, Jamie, Bogers, Laurens, Melief, Marie-José, Koetzier, Steven C., Blok, Katelijn M., Wierenga-Wolf, Annet F., de Vries, Helga E., Rip, Jasper, Corneth, Odilia B.J., Hendriks, Rudi W., Grenningloh, Roland, Boschert, Ursula, Smolders, Joost, van Luijn, Marvin M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Clinical Investigation
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462504/ https://www.ncbi.nlm.nih.gov/pubmed/35852869 http://dx.doi.org/10.1172/jci.insight.160909 |
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