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Extracellular Vesicles: The Next Generation Theranostic Nanomedicine for Inflammatory Bowel Disease
The recent rapid development in the field of extracellular vesicles (EVs) based nanotechnology has provided unprecedented opportunities for nanomedicine platforms. As natural nanocarriers, EVs such as exosomes, exosome-like nanoparticles and outer membrane vesicles (OMVs), have unique structure/comp...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462519/ https://www.ncbi.nlm.nih.gov/pubmed/36092245 http://dx.doi.org/10.2147/IJN.S370784 |
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author | Li, De-feng Yang, Mei-feng Xu, Jing Xu, Hao-ming Zhu, Min-zheng Liang, Yu-jie Zhang, Yuan Tian, Cheng-mei Nie, Yu-qiang Shi, Rui-yue Wang, Li-sheng Yao, Jun |
author_facet | Li, De-feng Yang, Mei-feng Xu, Jing Xu, Hao-ming Zhu, Min-zheng Liang, Yu-jie Zhang, Yuan Tian, Cheng-mei Nie, Yu-qiang Shi, Rui-yue Wang, Li-sheng Yao, Jun |
author_sort | Li, De-feng |
collection | PubMed |
description | The recent rapid development in the field of extracellular vesicles (EVs) based nanotechnology has provided unprecedented opportunities for nanomedicine platforms. As natural nanocarriers, EVs such as exosomes, exosome-like nanoparticles and outer membrane vesicles (OMVs), have unique structure/composition/morphology characteristics, and show excellent physical and chemical/biochemical properties, making them a new generation of theranostic nanomedicine. Here, we reviewed the characteristics of EVs from the perspective of their formation and biological function in inflammatory bowel disease (IBD). Moreover, EVs can crucially participate in the interaction and communication of intestinal epithelial cells (IECs)-immune cells-gut microbiota to regulate immune response, intestinal inflammation and intestinal homeostasis. Interestingly, based on current representative examples in the field of exosomes and exosome-like nanoparticles for IBD treatment, it is shown that plant, milk, and cells-derived exosomes and exosome-like nanoparticles can exert a therapeutic effect through their components, such as proteins, nucleic acid, and lipids. Moreover, several drug loading methods and target modification of exosomes are used to improve their therapeutic capability. We also discussed the application of exosomes and exosome-like nanoparticles in the treatment of IBD. In this review, we aim to better and more clearly clarify the underlying mechanisms of the EVs in the pathogenesis of IBD, and provide directions of exosomes and exosome-like nanoparticles mediated for IBD treatment. |
format | Online Article Text |
id | pubmed-9462519 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-94625192022-09-10 Extracellular Vesicles: The Next Generation Theranostic Nanomedicine for Inflammatory Bowel Disease Li, De-feng Yang, Mei-feng Xu, Jing Xu, Hao-ming Zhu, Min-zheng Liang, Yu-jie Zhang, Yuan Tian, Cheng-mei Nie, Yu-qiang Shi, Rui-yue Wang, Li-sheng Yao, Jun Int J Nanomedicine Review The recent rapid development in the field of extracellular vesicles (EVs) based nanotechnology has provided unprecedented opportunities for nanomedicine platforms. As natural nanocarriers, EVs such as exosomes, exosome-like nanoparticles and outer membrane vesicles (OMVs), have unique structure/composition/morphology characteristics, and show excellent physical and chemical/biochemical properties, making them a new generation of theranostic nanomedicine. Here, we reviewed the characteristics of EVs from the perspective of their formation and biological function in inflammatory bowel disease (IBD). Moreover, EVs can crucially participate in the interaction and communication of intestinal epithelial cells (IECs)-immune cells-gut microbiota to regulate immune response, intestinal inflammation and intestinal homeostasis. Interestingly, based on current representative examples in the field of exosomes and exosome-like nanoparticles for IBD treatment, it is shown that plant, milk, and cells-derived exosomes and exosome-like nanoparticles can exert a therapeutic effect through their components, such as proteins, nucleic acid, and lipids. Moreover, several drug loading methods and target modification of exosomes are used to improve their therapeutic capability. We also discussed the application of exosomes and exosome-like nanoparticles in the treatment of IBD. In this review, we aim to better and more clearly clarify the underlying mechanisms of the EVs in the pathogenesis of IBD, and provide directions of exosomes and exosome-like nanoparticles mediated for IBD treatment. Dove 2022-09-05 /pmc/articles/PMC9462519/ /pubmed/36092245 http://dx.doi.org/10.2147/IJN.S370784 Text en © 2022 Li et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Review Li, De-feng Yang, Mei-feng Xu, Jing Xu, Hao-ming Zhu, Min-zheng Liang, Yu-jie Zhang, Yuan Tian, Cheng-mei Nie, Yu-qiang Shi, Rui-yue Wang, Li-sheng Yao, Jun Extracellular Vesicles: The Next Generation Theranostic Nanomedicine for Inflammatory Bowel Disease |
title | Extracellular Vesicles: The Next Generation Theranostic Nanomedicine for Inflammatory Bowel Disease |
title_full | Extracellular Vesicles: The Next Generation Theranostic Nanomedicine for Inflammatory Bowel Disease |
title_fullStr | Extracellular Vesicles: The Next Generation Theranostic Nanomedicine for Inflammatory Bowel Disease |
title_full_unstemmed | Extracellular Vesicles: The Next Generation Theranostic Nanomedicine for Inflammatory Bowel Disease |
title_short | Extracellular Vesicles: The Next Generation Theranostic Nanomedicine for Inflammatory Bowel Disease |
title_sort | extracellular vesicles: the next generation theranostic nanomedicine for inflammatory bowel disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462519/ https://www.ncbi.nlm.nih.gov/pubmed/36092245 http://dx.doi.org/10.2147/IJN.S370784 |
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