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Application of physiologically-based pharmacokinetic/pharmacodynamic models to evaluate the interaction between nifedipine and apatinib

Aim: It has been found that the co-administration of nifedipine with apatinib could cause exposure changes of nifedipine in vivo. But, whether this pharmacokinetic drug-drug interaction (DDI) between nifedipine and apatinib could enhance the antihypertensive effect of nifedipine, causing sever chang...

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Detalles Bibliográficos
Autores principales:	Liu, Hongrui, Yu, Yiqun, Liu, Lu, Wang, Chunyan, Guo, Nan, Wang, Xiaojuan, Xiang, Xiaoqiang, Han, Bing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462537/ https://www.ncbi.nlm.nih.gov/pubmed/36091758 http://dx.doi.org/10.3389/fphar.2022.970539

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