A Case of Secondary Pulmonary Syphilis – The Utility of mNGS in Bronchoalveolar Lavage Fluid: A Case Report

Syphilis is a sexually transmitted infectious disease caused by Treponema pallidum. Here, we report a rare case of secondary pulmonary syphilis, which was diagnosed by metagenomic next-generation sequencing (mNGS) in bronchoalveolar lavage fluid (BALF). Direct pulmonary involvement by T. pallidum wa...

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Detalles Bibliográficos
Autores principales: Yang, Xue, Wu, Weigang, Wang, Yongjie, Wu, Wen, Huang, Xia, Xu, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462547/
https://www.ncbi.nlm.nih.gov/pubmed/36090605
http://dx.doi.org/10.2147/IDR.S373711
Descripción
Sumario:Syphilis is a sexually transmitted infectious disease caused by Treponema pallidum. Here, we report a rare case of secondary pulmonary syphilis, which was diagnosed by metagenomic next-generation sequencing (mNGS) in bronchoalveolar lavage fluid (BALF). Direct pulmonary involvement by T. pallidum was suggested by a positive mNGS result in BALF. One month after treatment with benzathine penicillin G (2.4 million units, three doses), a repeated CT scan showed the radiological resolution. To our knowledge, this is the first reported case of secondary pulmonary syphilis diagnosed by mNGS in BALF.

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