A Case of Secondary Pulmonary Syphilis – The Utility of mNGS in Bronchoalveolar Lavage Fluid: A Case Report

Syphilis is a sexually transmitted infectious disease caused by Treponema pallidum. Here, we report a rare case of secondary pulmonary syphilis, which was diagnosed by metagenomic next-generation sequencing (mNGS) in bronchoalveolar lavage fluid (BALF). Direct pulmonary involvement by T. pallidum wa...

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Autores principales: Yang, Xue, Wu, Weigang, Wang, Yongjie, Wu, Wen, Huang, Xia, Xu, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462547/
https://www.ncbi.nlm.nih.gov/pubmed/36090605
http://dx.doi.org/10.2147/IDR.S373711
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author Yang, Xue
Wu, Weigang
Wang, Yongjie
Wu, Wen
Huang, Xia
Xu, Li
author_facet Yang, Xue
Wu, Weigang
Wang, Yongjie
Wu, Wen
Huang, Xia
Xu, Li
author_sort Yang, Xue
collection PubMed
description Syphilis is a sexually transmitted infectious disease caused by Treponema pallidum. Here, we report a rare case of secondary pulmonary syphilis, which was diagnosed by metagenomic next-generation sequencing (mNGS) in bronchoalveolar lavage fluid (BALF). Direct pulmonary involvement by T. pallidum was suggested by a positive mNGS result in BALF. One month after treatment with benzathine penicillin G (2.4 million units, three doses), a repeated CT scan showed the radiological resolution. To our knowledge, this is the first reported case of secondary pulmonary syphilis diagnosed by mNGS in BALF.
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spelling pubmed-94625472022-09-10 A Case of Secondary Pulmonary Syphilis – The Utility of mNGS in Bronchoalveolar Lavage Fluid: A Case Report Yang, Xue Wu, Weigang Wang, Yongjie Wu, Wen Huang, Xia Xu, Li Infect Drug Resist Case Report Syphilis is a sexually transmitted infectious disease caused by Treponema pallidum. Here, we report a rare case of secondary pulmonary syphilis, which was diagnosed by metagenomic next-generation sequencing (mNGS) in bronchoalveolar lavage fluid (BALF). Direct pulmonary involvement by T. pallidum was suggested by a positive mNGS result in BALF. One month after treatment with benzathine penicillin G (2.4 million units, three doses), a repeated CT scan showed the radiological resolution. To our knowledge, this is the first reported case of secondary pulmonary syphilis diagnosed by mNGS in BALF. Dove 2022-09-05 /pmc/articles/PMC9462547/ /pubmed/36090605 http://dx.doi.org/10.2147/IDR.S373711 Text en © 2022 Yang et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Case Report
Yang, Xue
Wu, Weigang
Wang, Yongjie
Wu, Wen
Huang, Xia
Xu, Li
A Case of Secondary Pulmonary Syphilis – The Utility of mNGS in Bronchoalveolar Lavage Fluid: A Case Report
title A Case of Secondary Pulmonary Syphilis – The Utility of mNGS in Bronchoalveolar Lavage Fluid: A Case Report
title_full A Case of Secondary Pulmonary Syphilis – The Utility of mNGS in Bronchoalveolar Lavage Fluid: A Case Report
title_fullStr A Case of Secondary Pulmonary Syphilis – The Utility of mNGS in Bronchoalveolar Lavage Fluid: A Case Report
title_full_unstemmed A Case of Secondary Pulmonary Syphilis – The Utility of mNGS in Bronchoalveolar Lavage Fluid: A Case Report
title_short A Case of Secondary Pulmonary Syphilis – The Utility of mNGS in Bronchoalveolar Lavage Fluid: A Case Report
title_sort case of secondary pulmonary syphilis – the utility of mngs in bronchoalveolar lavage fluid: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462547/
https://www.ncbi.nlm.nih.gov/pubmed/36090605
http://dx.doi.org/10.2147/IDR.S373711
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