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The associations between ADHD, pain, inflammation, and quality of life in children and adolescents—a clinical study protocol

New research shows that the prevalence of neurodevelopmental disorders, such as attention-deficit/hyperactivity disorder (ADHD), is increased in children and adolescents as well as in adults with chronic pain, compared to those without chronic pain. Children and adolescents with ADHD also have an in...

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Autores principales: Kerekes, Nóra, Lundqvist, Sara, Schubert Hjalmarsson, Elke, Torinsson Naluai, Åsa, Kantzer, Anne-Katrin, Knez, Rajna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462574/
https://www.ncbi.nlm.nih.gov/pubmed/36083951
http://dx.doi.org/10.1371/journal.pone.0273653
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author Kerekes, Nóra
Lundqvist, Sara
Schubert Hjalmarsson, Elke
Torinsson Naluai, Åsa
Kantzer, Anne-Katrin
Knez, Rajna
author_facet Kerekes, Nóra
Lundqvist, Sara
Schubert Hjalmarsson, Elke
Torinsson Naluai, Åsa
Kantzer, Anne-Katrin
Knez, Rajna
author_sort Kerekes, Nóra
collection PubMed
description New research shows that the prevalence of neurodevelopmental disorders, such as attention-deficit/hyperactivity disorder (ADHD), is increased in children and adolescents as well as in adults with chronic pain, compared to those without chronic pain. Children and adolescents with ADHD also have an increased incidence of various physical conditions associated with pain, and they more frequently suffer from inflammatory diseases. Moreover, parents of children with ADHD can often suffer from pain conditions. These epidemiological and clinical observations form the scientific basis of our study, which aims to map the relationships between ADHD, altered pain experiences/central sensitization, and inflammation in children and adolescents. We will investigate the presence of central sensitization in children and adolescents with newly diagnosed ADHD and compare it with those who have not been diagnosed with ADHD. Participants (and their biological parents) will complete surveys about their somatic health, pain experience, and quality of life. Biological samples (saliva and stool) will be collected, aiming to utilize proteome and metabolome data to discover disease mechanisms and to predict, prevent and treat them. The results from our investigation should enable an expanded understanding of the pathophysiology behind both ADHD and pain/central sensitization. Presently, there are no established protocols for addressing psychiatric symptoms when examining patients with pain conditions in a somatic care setting, nor is there any knowledge of offering patients with ADHD or other neurodevelopmental disorders adapted treatments for pain conditions. Our results, therefore, can contribute to the development of new treatment strategies for pathological pain conditions in children and adolescents with ADHD. They may also increase awareness about and provide opportunities for the treatment of attention and impulse control problems in children and adolescents with pain syndromes.
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spelling pubmed-94625742022-09-10 The associations between ADHD, pain, inflammation, and quality of life in children and adolescents—a clinical study protocol Kerekes, Nóra Lundqvist, Sara Schubert Hjalmarsson, Elke Torinsson Naluai, Åsa Kantzer, Anne-Katrin Knez, Rajna PLoS One Study Protocol New research shows that the prevalence of neurodevelopmental disorders, such as attention-deficit/hyperactivity disorder (ADHD), is increased in children and adolescents as well as in adults with chronic pain, compared to those without chronic pain. Children and adolescents with ADHD also have an increased incidence of various physical conditions associated with pain, and they more frequently suffer from inflammatory diseases. Moreover, parents of children with ADHD can often suffer from pain conditions. These epidemiological and clinical observations form the scientific basis of our study, which aims to map the relationships between ADHD, altered pain experiences/central sensitization, and inflammation in children and adolescents. We will investigate the presence of central sensitization in children and adolescents with newly diagnosed ADHD and compare it with those who have not been diagnosed with ADHD. Participants (and their biological parents) will complete surveys about their somatic health, pain experience, and quality of life. Biological samples (saliva and stool) will be collected, aiming to utilize proteome and metabolome data to discover disease mechanisms and to predict, prevent and treat them. The results from our investigation should enable an expanded understanding of the pathophysiology behind both ADHD and pain/central sensitization. Presently, there are no established protocols for addressing psychiatric symptoms when examining patients with pain conditions in a somatic care setting, nor is there any knowledge of offering patients with ADHD or other neurodevelopmental disorders adapted treatments for pain conditions. Our results, therefore, can contribute to the development of new treatment strategies for pathological pain conditions in children and adolescents with ADHD. They may also increase awareness about and provide opportunities for the treatment of attention and impulse control problems in children and adolescents with pain syndromes. Public Library of Science 2022-09-09 /pmc/articles/PMC9462574/ /pubmed/36083951 http://dx.doi.org/10.1371/journal.pone.0273653 Text en © 2022 Kerekes et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Study Protocol
Kerekes, Nóra
Lundqvist, Sara
Schubert Hjalmarsson, Elke
Torinsson Naluai, Åsa
Kantzer, Anne-Katrin
Knez, Rajna
The associations between ADHD, pain, inflammation, and quality of life in children and adolescents—a clinical study protocol
title The associations between ADHD, pain, inflammation, and quality of life in children and adolescents—a clinical study protocol
title_full The associations between ADHD, pain, inflammation, and quality of life in children and adolescents—a clinical study protocol
title_fullStr The associations between ADHD, pain, inflammation, and quality of life in children and adolescents—a clinical study protocol
title_full_unstemmed The associations between ADHD, pain, inflammation, and quality of life in children and adolescents—a clinical study protocol
title_short The associations between ADHD, pain, inflammation, and quality of life in children and adolescents—a clinical study protocol
title_sort associations between adhd, pain, inflammation, and quality of life in children and adolescents—a clinical study protocol
topic Study Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462574/
https://www.ncbi.nlm.nih.gov/pubmed/36083951
http://dx.doi.org/10.1371/journal.pone.0273653
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