Cargando…
Effectiveness of new selenium-enriched mutated probiotics in reducing inflammatory effects of piroxicam medication in liver and kidney
Piroxicam is used to treat the pain, swelling, and stiffness associated with osteoarthritis and rheumatoid arthritis, but it has many side effects, such as hypertension, elevation of liver enzymes, and hepatitis. This study used selenium-enriched probiotics to reduce the side effects of piroxicam on...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462618/ https://www.ncbi.nlm.nih.gov/pubmed/36085399 http://dx.doi.org/10.1007/s10787-022-01064-1 |
_version_ | 1784787226220036096 |
---|---|
author | Darwish, Ahmed Mohamed Khattab, Abd El-Nasser A. Abd El-Razik, Khaled A. Othman, Sarah I. Allam, Ahmed A. Abu-Taweel, Gasem M. |
author_facet | Darwish, Ahmed Mohamed Khattab, Abd El-Nasser A. Abd El-Razik, Khaled A. Othman, Sarah I. Allam, Ahmed A. Abu-Taweel, Gasem M. |
author_sort | Darwish, Ahmed Mohamed |
collection | PubMed |
description | Piroxicam is used to treat the pain, swelling, and stiffness associated with osteoarthritis and rheumatoid arthritis, but it has many side effects, such as hypertension, elevation of liver enzymes, and hepatitis. This study used selenium-enriched probiotics to reduce the side effects of piroxicam on the liver and kidney tissues and functions. Forty-eight male albino mice were randomly assigned to control, piroxicam (P), piroxicam plus selenium-enriched Lactobacillus plantarum PSe40/60/1 (P + SP), piroxicam plus selenium-enriched Bifidobacterium longum BSe50/20/1 (P + SB), selenium-enriched L. plantarum PSe40/60/1 (SP), and selenium-enriched B. longum BSe50/20/1 (SB) groups. In this study, the function of the liver and kidney was biochemically determined; the histopathology of the liver and kidney tissues was microscopically examined and the expression of inflammatory and anti-inflammatory genes in liver and kidney tissues was determined by quantitative real-time polymerase chain reaction (qRT-PCR). Liver and kidney functions were significantly reduced in the piroxicam group compared with control. Liver and kidney tissues were damaged in the piroxicam group while they appeared more or less normal in the SB group. The expression of inflammatory genes was significantly up-regulated in the liver and kidney tissues of the piroxicam group compared to the control group. The expression of anti-inflammatory genes was significantly down-regulated in the liver and kidney of the piroxicam group and up-regulated in the liver and kidney of the SB group compared to the control group. Therefore, these mutated strains of probiotics were useful in reducing the side effects of the piroxicam drug on the liver and kidney. |
format | Online Article Text |
id | pubmed-9462618 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-94626182022-09-10 Effectiveness of new selenium-enriched mutated probiotics in reducing inflammatory effects of piroxicam medication in liver and kidney Darwish, Ahmed Mohamed Khattab, Abd El-Nasser A. Abd El-Razik, Khaled A. Othman, Sarah I. Allam, Ahmed A. Abu-Taweel, Gasem M. Inflammopharmacology Original Article Piroxicam is used to treat the pain, swelling, and stiffness associated with osteoarthritis and rheumatoid arthritis, but it has many side effects, such as hypertension, elevation of liver enzymes, and hepatitis. This study used selenium-enriched probiotics to reduce the side effects of piroxicam on the liver and kidney tissues and functions. Forty-eight male albino mice were randomly assigned to control, piroxicam (P), piroxicam plus selenium-enriched Lactobacillus plantarum PSe40/60/1 (P + SP), piroxicam plus selenium-enriched Bifidobacterium longum BSe50/20/1 (P + SB), selenium-enriched L. plantarum PSe40/60/1 (SP), and selenium-enriched B. longum BSe50/20/1 (SB) groups. In this study, the function of the liver and kidney was biochemically determined; the histopathology of the liver and kidney tissues was microscopically examined and the expression of inflammatory and anti-inflammatory genes in liver and kidney tissues was determined by quantitative real-time polymerase chain reaction (qRT-PCR). Liver and kidney functions were significantly reduced in the piroxicam group compared with control. Liver and kidney tissues were damaged in the piroxicam group while they appeared more or less normal in the SB group. The expression of inflammatory genes was significantly up-regulated in the liver and kidney tissues of the piroxicam group compared to the control group. The expression of anti-inflammatory genes was significantly down-regulated in the liver and kidney of the piroxicam group and up-regulated in the liver and kidney of the SB group compared to the control group. Therefore, these mutated strains of probiotics were useful in reducing the side effects of the piroxicam drug on the liver and kidney. Springer International Publishing 2022-09-09 2022 /pmc/articles/PMC9462618/ /pubmed/36085399 http://dx.doi.org/10.1007/s10787-022-01064-1 Text en © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022, Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Original Article Darwish, Ahmed Mohamed Khattab, Abd El-Nasser A. Abd El-Razik, Khaled A. Othman, Sarah I. Allam, Ahmed A. Abu-Taweel, Gasem M. Effectiveness of new selenium-enriched mutated probiotics in reducing inflammatory effects of piroxicam medication in liver and kidney |
title | Effectiveness of new selenium-enriched mutated probiotics in reducing inflammatory effects of piroxicam medication in liver and kidney |
title_full | Effectiveness of new selenium-enriched mutated probiotics in reducing inflammatory effects of piroxicam medication in liver and kidney |
title_fullStr | Effectiveness of new selenium-enriched mutated probiotics in reducing inflammatory effects of piroxicam medication in liver and kidney |
title_full_unstemmed | Effectiveness of new selenium-enriched mutated probiotics in reducing inflammatory effects of piroxicam medication in liver and kidney |
title_short | Effectiveness of new selenium-enriched mutated probiotics in reducing inflammatory effects of piroxicam medication in liver and kidney |
title_sort | effectiveness of new selenium-enriched mutated probiotics in reducing inflammatory effects of piroxicam medication in liver and kidney |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462618/ https://www.ncbi.nlm.nih.gov/pubmed/36085399 http://dx.doi.org/10.1007/s10787-022-01064-1 |
work_keys_str_mv | AT darwishahmedmohamed effectivenessofnewseleniumenrichedmutatedprobioticsinreducinginflammatoryeffectsofpiroxicammedicationinliverandkidney AT khattababdelnassera effectivenessofnewseleniumenrichedmutatedprobioticsinreducinginflammatoryeffectsofpiroxicammedicationinliverandkidney AT abdelrazikkhaleda effectivenessofnewseleniumenrichedmutatedprobioticsinreducinginflammatoryeffectsofpiroxicammedicationinliverandkidney AT othmansarahi effectivenessofnewseleniumenrichedmutatedprobioticsinreducinginflammatoryeffectsofpiroxicammedicationinliverandkidney AT allamahmeda effectivenessofnewseleniumenrichedmutatedprobioticsinreducinginflammatoryeffectsofpiroxicammedicationinliverandkidney AT abutaweelgasemm effectivenessofnewseleniumenrichedmutatedprobioticsinreducinginflammatoryeffectsofpiroxicammedicationinliverandkidney |