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Reshaping the path of mild cognitive impairment by refining exercise prescription: a study protocol of a randomized controlled trial to understand the “what,” “for whom,” and “how” of exercise to promote cognitive function

BACKGROUND: Targeted exercise training is a promising strategy for promoting cognitive function and preventing dementia in older age. Despite the utility of exercise as an intervention, variation still exists in exercise-induced cognitive gains and questions remain regarding the type of training (i....

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Autores principales: Barha, Cindy K., Falck, Ryan S., Best, John R., Nagamatsu, Lindsay S., Hsiung, Ging-Yuek Robin, Sheel, A. William, Hsu, Chun Liang, Kramer, Arthur F., Voss, Michelle W., Erickson, Kirk I., Davis, Jennifer C., Shoemaker, J. Kevin, Boyd, Lara, Crockett, Rachel A., ten Brinke, Lisanne, Bherer, Louis, Singer, Joel, Galea, Liisa A. M., Jacova, Claudia, Bullock, Alexis, Grant, Sofia, Liu-Ambrose, Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462619/
https://www.ncbi.nlm.nih.gov/pubmed/36085237
http://dx.doi.org/10.1186/s13063-022-06699-7
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author Barha, Cindy K.
Falck, Ryan S.
Best, John R.
Nagamatsu, Lindsay S.
Hsiung, Ging-Yuek Robin
Sheel, A. William
Hsu, Chun Liang
Kramer, Arthur F.
Voss, Michelle W.
Erickson, Kirk I.
Davis, Jennifer C.
Shoemaker, J. Kevin
Boyd, Lara
Crockett, Rachel A.
ten Brinke, Lisanne
Bherer, Louis
Singer, Joel
Galea, Liisa A. M.
Jacova, Claudia
Bullock, Alexis
Grant, Sofia
Liu-Ambrose, Teresa
author_facet Barha, Cindy K.
Falck, Ryan S.
Best, John R.
Nagamatsu, Lindsay S.
Hsiung, Ging-Yuek Robin
Sheel, A. William
Hsu, Chun Liang
Kramer, Arthur F.
Voss, Michelle W.
Erickson, Kirk I.
Davis, Jennifer C.
Shoemaker, J. Kevin
Boyd, Lara
Crockett, Rachel A.
ten Brinke, Lisanne
Bherer, Louis
Singer, Joel
Galea, Liisa A. M.
Jacova, Claudia
Bullock, Alexis
Grant, Sofia
Liu-Ambrose, Teresa
author_sort Barha, Cindy K.
collection PubMed
description BACKGROUND: Targeted exercise training is a promising strategy for promoting cognitive function and preventing dementia in older age. Despite the utility of exercise as an intervention, variation still exists in exercise-induced cognitive gains and questions remain regarding the type of training (i.e., what), as well as moderators (i.e., for whom) and mechanisms (i.e., how) of benefit. Both aerobic training (AT) and resistance training (RT) enhance cognitive function in older adults without cognitive impairment; however, the vast majority of trials have focused exclusively on AT. Thus, more research is needed on RT, as well as on the combination of AT and RT, in older adults with mild cognitive impairment (MCI), a prodromal stage of dementia. Therefore, we aim to conduct a 6-month, 2 × 2 factorial randomized controlled trial in older adults with MCI to assess the individual effects of AT and RT, and the combined effect of AT and RT on cognitive function and to determine the possible underlying biological mechanisms. METHODS: Two hundred and sixteen community-dwelling adults, aged 65 to 85 years, with MCI from metropolitan Vancouver will be recruited to participate in this study. Randomization will be stratified by biological sex and participants will be randomly allocated to one of the four experimental groups: (1) 4×/week balance and tone (BAT; i.e., active control); (2) combined 2×/week AT + 2×/week RT; (3) 2×/week AT + 2×/week BAT; or (4) 2×/week RT + 2×/week BAT. The primary outcome is cognitive function as measured by the Alzheimer’s Disease Assessment Scale-Cognitive-Plus. Secondary outcomes include cognitive function, health-related quality of life, physical function, actigraphy measures, questionnaires, and falls. Outcomes will be measured at baseline, 6 months (i.e., trial completion), and 18 months (i.e., 12-month follow-up). DISCUSSION: Establishing the efficacy of different types and combinations of exercise training to minimize cognitive decline will advance our ability to prescribe exercise as “medicine” to treat MCI and delay the onset and progression of dementia. This trial is extremely timely as cognitive impairment and dementia pose a growing threat to global public health. TRIAL REGISTRATION: ClinicalTrials.gov NCT02737878. Registered on April 14, 2016.
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spelling pubmed-94626192022-09-10 Reshaping the path of mild cognitive impairment by refining exercise prescription: a study protocol of a randomized controlled trial to understand the “what,” “for whom,” and “how” of exercise to promote cognitive function Barha, Cindy K. Falck, Ryan S. Best, John R. Nagamatsu, Lindsay S. Hsiung, Ging-Yuek Robin Sheel, A. William Hsu, Chun Liang Kramer, Arthur F. Voss, Michelle W. Erickson, Kirk I. Davis, Jennifer C. Shoemaker, J. Kevin Boyd, Lara Crockett, Rachel A. ten Brinke, Lisanne Bherer, Louis Singer, Joel Galea, Liisa A. M. Jacova, Claudia Bullock, Alexis Grant, Sofia Liu-Ambrose, Teresa Trials Study Protocol BACKGROUND: Targeted exercise training is a promising strategy for promoting cognitive function and preventing dementia in older age. Despite the utility of exercise as an intervention, variation still exists in exercise-induced cognitive gains and questions remain regarding the type of training (i.e., what), as well as moderators (i.e., for whom) and mechanisms (i.e., how) of benefit. Both aerobic training (AT) and resistance training (RT) enhance cognitive function in older adults without cognitive impairment; however, the vast majority of trials have focused exclusively on AT. Thus, more research is needed on RT, as well as on the combination of AT and RT, in older adults with mild cognitive impairment (MCI), a prodromal stage of dementia. Therefore, we aim to conduct a 6-month, 2 × 2 factorial randomized controlled trial in older adults with MCI to assess the individual effects of AT and RT, and the combined effect of AT and RT on cognitive function and to determine the possible underlying biological mechanisms. METHODS: Two hundred and sixteen community-dwelling adults, aged 65 to 85 years, with MCI from metropolitan Vancouver will be recruited to participate in this study. Randomization will be stratified by biological sex and participants will be randomly allocated to one of the four experimental groups: (1) 4×/week balance and tone (BAT; i.e., active control); (2) combined 2×/week AT + 2×/week RT; (3) 2×/week AT + 2×/week BAT; or (4) 2×/week RT + 2×/week BAT. The primary outcome is cognitive function as measured by the Alzheimer’s Disease Assessment Scale-Cognitive-Plus. Secondary outcomes include cognitive function, health-related quality of life, physical function, actigraphy measures, questionnaires, and falls. Outcomes will be measured at baseline, 6 months (i.e., trial completion), and 18 months (i.e., 12-month follow-up). DISCUSSION: Establishing the efficacy of different types and combinations of exercise training to minimize cognitive decline will advance our ability to prescribe exercise as “medicine” to treat MCI and delay the onset and progression of dementia. This trial is extremely timely as cognitive impairment and dementia pose a growing threat to global public health. TRIAL REGISTRATION: ClinicalTrials.gov NCT02737878. Registered on April 14, 2016. BioMed Central 2022-09-09 /pmc/articles/PMC9462619/ /pubmed/36085237 http://dx.doi.org/10.1186/s13063-022-06699-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Study Protocol
Barha, Cindy K.
Falck, Ryan S.
Best, John R.
Nagamatsu, Lindsay S.
Hsiung, Ging-Yuek Robin
Sheel, A. William
Hsu, Chun Liang
Kramer, Arthur F.
Voss, Michelle W.
Erickson, Kirk I.
Davis, Jennifer C.
Shoemaker, J. Kevin
Boyd, Lara
Crockett, Rachel A.
ten Brinke, Lisanne
Bherer, Louis
Singer, Joel
Galea, Liisa A. M.
Jacova, Claudia
Bullock, Alexis
Grant, Sofia
Liu-Ambrose, Teresa
Reshaping the path of mild cognitive impairment by refining exercise prescription: a study protocol of a randomized controlled trial to understand the “what,” “for whom,” and “how” of exercise to promote cognitive function
title Reshaping the path of mild cognitive impairment by refining exercise prescription: a study protocol of a randomized controlled trial to understand the “what,” “for whom,” and “how” of exercise to promote cognitive function
title_full Reshaping the path of mild cognitive impairment by refining exercise prescription: a study protocol of a randomized controlled trial to understand the “what,” “for whom,” and “how” of exercise to promote cognitive function
title_fullStr Reshaping the path of mild cognitive impairment by refining exercise prescription: a study protocol of a randomized controlled trial to understand the “what,” “for whom,” and “how” of exercise to promote cognitive function
title_full_unstemmed Reshaping the path of mild cognitive impairment by refining exercise prescription: a study protocol of a randomized controlled trial to understand the “what,” “for whom,” and “how” of exercise to promote cognitive function
title_short Reshaping the path of mild cognitive impairment by refining exercise prescription: a study protocol of a randomized controlled trial to understand the “what,” “for whom,” and “how” of exercise to promote cognitive function
title_sort reshaping the path of mild cognitive impairment by refining exercise prescription: a study protocol of a randomized controlled trial to understand the “what,” “for whom,” and “how” of exercise to promote cognitive function
topic Study Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462619/
https://www.ncbi.nlm.nih.gov/pubmed/36085237
http://dx.doi.org/10.1186/s13063-022-06699-7
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