Surface translocation of ACE2 and TMPRSS2 upon TLR4/7/8 activation is required for SARS-CoV-2 infection in circulating monocytes

Infection of human peripheral blood cells by SARS-CoV-2 has been debated because immune cells lack mRNA expression of both angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease type 2 (TMPRSS2). Herein we demonstrate that resting primary monocytes harbor abundant cytoplasmic ACE2...

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Detalles Bibliográficos
Autores principales: Yao, Yi, Subedi, Kalpana, Liu, Tingting, Khalasawi, Namir, Pretto-Kernahan, Carla Diana, Wotring, Jesse William, Wang, Jie, Yin, Congcong, Jiang, Aimin, Fu, Chunmei, Dimitrion, Peter, Li, Jia, Veenstra, Jesse, Yi, Qijun, McKinnon, Kathy, McKinnon, John Ernest, Sexton, Jonathan Zachary, Zhou, Li, Mi, Qing-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462622/
https://www.ncbi.nlm.nih.gov/pubmed/36085197
http://dx.doi.org/10.1038/s41421-022-00453-8

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