Phase separation in immune regulation and immune-related diseases

Phase separation is an emerging paradigm for understanding the biochemical interactions between proteins, DNA, and RNA. Research over the past decade has provided mounting evidence that phase separation modulates a great variety of cellular activities. Particularly, phase separation is directly rele...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Ning, Dong, Hao, Shao, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462646/
https://www.ncbi.nlm.nih.gov/pubmed/36085373
http://dx.doi.org/10.1007/s00109-022-02253-9
_version_ 1784787233111277568
author Huang, Ning
Dong, Hao
Shao, Bin
author_facet Huang, Ning
Dong, Hao
Shao, Bin
author_sort Huang, Ning
collection PubMed
description Phase separation is an emerging paradigm for understanding the biochemical interactions between proteins, DNA, and RNA. Research over the past decade has provided mounting evidence that phase separation modulates a great variety of cellular activities. Particularly, phase separation is directly relevant to immune signaling, immune cells, and immune-related diseases like cancer, neurodegenerative diseases, and even SARS-CoV-2. In this review, we summarized current knowledge of phase separation in immunology and emerging findings related to immune responses as they enable possible treatment approaches.
format Online
Article
Text
id pubmed-9462646
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Springer Berlin Heidelberg
record_format MEDLINE/PubMed
spelling pubmed-94626462022-09-10 Phase separation in immune regulation and immune-related diseases Huang, Ning Dong, Hao Shao, Bin J Mol Med (Berl) Review Phase separation is an emerging paradigm for understanding the biochemical interactions between proteins, DNA, and RNA. Research over the past decade has provided mounting evidence that phase separation modulates a great variety of cellular activities. Particularly, phase separation is directly relevant to immune signaling, immune cells, and immune-related diseases like cancer, neurodegenerative diseases, and even SARS-CoV-2. In this review, we summarized current knowledge of phase separation in immunology and emerging findings related to immune responses as they enable possible treatment approaches. Springer Berlin Heidelberg 2022-09-09 2022 /pmc/articles/PMC9462646/ /pubmed/36085373 http://dx.doi.org/10.1007/s00109-022-02253-9 Text en © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022, Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review
Huang, Ning
Dong, Hao
Shao, Bin
Phase separation in immune regulation and immune-related diseases
title Phase separation in immune regulation and immune-related diseases
title_full Phase separation in immune regulation and immune-related diseases
title_fullStr Phase separation in immune regulation and immune-related diseases
title_full_unstemmed Phase separation in immune regulation and immune-related diseases
title_short Phase separation in immune regulation and immune-related diseases
title_sort phase separation in immune regulation and immune-related diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462646/
https://www.ncbi.nlm.nih.gov/pubmed/36085373
http://dx.doi.org/10.1007/s00109-022-02253-9
work_keys_str_mv AT huangning phaseseparationinimmuneregulationandimmunerelateddiseases
AT donghao phaseseparationinimmuneregulationandimmunerelateddiseases
AT shaobin phaseseparationinimmuneregulationandimmunerelateddiseases

Ejemplares similares