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Nonlinear dynamics of a SIRI model incorporating the impact of information and saturated treatment with optimal control

In this article, we propose and analyze an infectious disease model with reinfection and investigate disease dynamics by incorporating saturated treatment and information effect. In the model, we consider the case where an individual’s immunity deteriorates and they become infected again after recov...

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Autores principales: Srivastava, Akriti, Sonu, Srivastava, Prashant K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462650/
https://www.ncbi.nlm.nih.gov/pubmed/36106085
http://dx.doi.org/10.1140/epjp/s13360-022-03201-9
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author Srivastava, Akriti
Sonu
Srivastava, Prashant K.
author_facet Srivastava, Akriti
Sonu
Srivastava, Prashant K.
author_sort Srivastava, Akriti
collection PubMed
description In this article, we propose and analyze an infectious disease model with reinfection and investigate disease dynamics by incorporating saturated treatment and information effect. In the model, we consider the case where an individual’s immunity deteriorates and they become infected again after recovering. According to our findings, multiple steady states and backward bifurcation may occur as a result of treatment saturation. Further, if treatment is available for all, the disease will be eradicated provided [Formula: see text] ; however, because limited medical resources caused saturation in treatment, the disease may persist even if [Formula: see text] The global stability of the unique endemic steady state is established using a geometric approach. We also establish certain conditions on the transmission rate for the occurrence of periodic oscillations in the model system. Among nonlinear dynamics, we show supercritical Hopf bifurcation, bi-stability, backward Hopf bifurcation, and double Hopf bifurcation. To illustrate and validate our theoretical results, we present numerical examples. We found that when disease information coverage is high, infection cases fall considerably, and the disease persists when the reinfection rate is high. We then extend our model by incorporating two time-dependent controls, namely inhibitory interventions and treatment. Using Pontryagin’s maximum principle, we prove the existence of optimal control paths and find the optimal pair of controls. According to our numerical simulations, the second control is less effective than the first. Furthermore, while implementing a single intervention at a time may be effective, combining both interventions is most effective in reducing disease burden and cost.
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spelling pubmed-94626502022-09-10 Nonlinear dynamics of a SIRI model incorporating the impact of information and saturated treatment with optimal control Srivastava, Akriti Sonu Srivastava, Prashant K. Eur Phys J Plus Regular Article In this article, we propose and analyze an infectious disease model with reinfection and investigate disease dynamics by incorporating saturated treatment and information effect. In the model, we consider the case where an individual’s immunity deteriorates and they become infected again after recovering. According to our findings, multiple steady states and backward bifurcation may occur as a result of treatment saturation. Further, if treatment is available for all, the disease will be eradicated provided [Formula: see text] ; however, because limited medical resources caused saturation in treatment, the disease may persist even if [Formula: see text] The global stability of the unique endemic steady state is established using a geometric approach. We also establish certain conditions on the transmission rate for the occurrence of periodic oscillations in the model system. Among nonlinear dynamics, we show supercritical Hopf bifurcation, bi-stability, backward Hopf bifurcation, and double Hopf bifurcation. To illustrate and validate our theoretical results, we present numerical examples. We found that when disease information coverage is high, infection cases fall considerably, and the disease persists when the reinfection rate is high. We then extend our model by incorporating two time-dependent controls, namely inhibitory interventions and treatment. Using Pontryagin’s maximum principle, we prove the existence of optimal control paths and find the optimal pair of controls. According to our numerical simulations, the second control is less effective than the first. Furthermore, while implementing a single intervention at a time may be effective, combining both interventions is most effective in reducing disease burden and cost. Springer Berlin Heidelberg 2022-09-09 2022 /pmc/articles/PMC9462650/ /pubmed/36106085 http://dx.doi.org/10.1140/epjp/s13360-022-03201-9 Text en © The Author(s), under exclusive licence to Società Italiana di Fisica and Springer-Verlag GmbH Germany, part of Springer Nature 2022, Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rights holder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Regular Article
Srivastava, Akriti
Sonu
Srivastava, Prashant K.
Nonlinear dynamics of a SIRI model incorporating the impact of information and saturated treatment with optimal control
title Nonlinear dynamics of a SIRI model incorporating the impact of information and saturated treatment with optimal control
title_full Nonlinear dynamics of a SIRI model incorporating the impact of information and saturated treatment with optimal control
title_fullStr Nonlinear dynamics of a SIRI model incorporating the impact of information and saturated treatment with optimal control
title_full_unstemmed Nonlinear dynamics of a SIRI model incorporating the impact of information and saturated treatment with optimal control
title_short Nonlinear dynamics of a SIRI model incorporating the impact of information and saturated treatment with optimal control
title_sort nonlinear dynamics of a siri model incorporating the impact of information and saturated treatment with optimal control
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462650/
https://www.ncbi.nlm.nih.gov/pubmed/36106085
http://dx.doi.org/10.1140/epjp/s13360-022-03201-9
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