Treatment Modalities for Dementia in Down’s Syndrome: A Literature Review

Down's syndrome (DS) is the most well-known chromosomal abnormality characterized by an extra chromosome 21 and multiple systemic issues. The higher production of amyloid precursor protein (APP), the precursor peptide of beta-amyloid, predisposes persons with DS to early Alzheimer's diseas...

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Autores principales: Lamsal Lamichhane, Smriti, Ramesh, Vaiishnavi, Opara, Collins O, Khan, Farhana Yaqoob, Kabiraj, Gargi, Kauser, Humaira, Palakeel, Jaimee J, Ali, Mazin, Chaduvula, Phani, Chhabra, Sanika, Mohammed, Lubna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462651/
https://www.ncbi.nlm.nih.gov/pubmed/36110433
http://dx.doi.org/10.7759/cureus.27881
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author Lamsal Lamichhane, Smriti
Ramesh, Vaiishnavi
Opara, Collins O
Khan, Farhana Yaqoob
Kabiraj, Gargi
Kauser, Humaira
Palakeel, Jaimee J
Ali, Mazin
Chaduvula, Phani
Chhabra, Sanika
Mohammed, Lubna
author_facet Lamsal Lamichhane, Smriti
Ramesh, Vaiishnavi
Opara, Collins O
Khan, Farhana Yaqoob
Kabiraj, Gargi
Kauser, Humaira
Palakeel, Jaimee J
Ali, Mazin
Chaduvula, Phani
Chhabra, Sanika
Mohammed, Lubna
author_sort Lamsal Lamichhane, Smriti
collection PubMed
description Down's syndrome (DS) is the most well-known chromosomal abnormality characterized by an extra chromosome 21 and multiple systemic issues. The higher production of amyloid precursor protein (APP), the precursor peptide of beta-amyloid, predisposes persons with DS to early Alzheimer's disease (AD). The prevalence of dementia has increased as a function of the extended life expectancy of persons with DS. Because we know little about the treatment of dementia in persons with DS, this review focuses on the pathophysiology and management strategies to improve the overall quality of life. 
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spelling pubmed-94626512022-09-14 Treatment Modalities for Dementia in Down’s Syndrome: A Literature Review Lamsal Lamichhane, Smriti Ramesh, Vaiishnavi Opara, Collins O Khan, Farhana Yaqoob Kabiraj, Gargi Kauser, Humaira Palakeel, Jaimee J Ali, Mazin Chaduvula, Phani Chhabra, Sanika Mohammed, Lubna Cureus Genetics Down's syndrome (DS) is the most well-known chromosomal abnormality characterized by an extra chromosome 21 and multiple systemic issues. The higher production of amyloid precursor protein (APP), the precursor peptide of beta-amyloid, predisposes persons with DS to early Alzheimer's disease (AD). The prevalence of dementia has increased as a function of the extended life expectancy of persons with DS. Because we know little about the treatment of dementia in persons with DS, this review focuses on the pathophysiology and management strategies to improve the overall quality of life.  Cureus 2022-08-11 /pmc/articles/PMC9462651/ /pubmed/36110433 http://dx.doi.org/10.7759/cureus.27881 Text en Copyright © 2022, Lamsal Lamichhane et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Genetics
Lamsal Lamichhane, Smriti
Ramesh, Vaiishnavi
Opara, Collins O
Khan, Farhana Yaqoob
Kabiraj, Gargi
Kauser, Humaira
Palakeel, Jaimee J
Ali, Mazin
Chaduvula, Phani
Chhabra, Sanika
Mohammed, Lubna
Treatment Modalities for Dementia in Down’s Syndrome: A Literature Review
title Treatment Modalities for Dementia in Down’s Syndrome: A Literature Review
title_full Treatment Modalities for Dementia in Down’s Syndrome: A Literature Review
title_fullStr Treatment Modalities for Dementia in Down’s Syndrome: A Literature Review
title_full_unstemmed Treatment Modalities for Dementia in Down’s Syndrome: A Literature Review
title_short Treatment Modalities for Dementia in Down’s Syndrome: A Literature Review
title_sort treatment modalities for dementia in down’s syndrome: a literature review
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462651/
https://www.ncbi.nlm.nih.gov/pubmed/36110433
http://dx.doi.org/10.7759/cureus.27881
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