Heat selection enables highly scalable methylome profiling in cell-free DNA for noninvasive monitoring of cancer patients

Genome-wide analysis of cell-free DNA methylation profile is a promising approach for sensitive and specific detection of many cancers. However, scaling such assays for clinical translation is impractical because of the high cost of whole-genome bisulfite sequencing. We show that the small fraction...

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Detalles Bibliográficos
Autores principales: Cheruba, Elsie, Viswanathan, Ramya, Wong, Pui-Mun, Womersley, Howard John, Han, Shuting, Tay, Brenda, Lau, Yiting, Gan, Anna, Poon, Polly S. Y., Skanderup, Anders, Ng, Sarah B., Chok, Aik Yong, Chong, Dawn Qingqing, Tan, Iain Beehuat, Cheow, Lih Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462700/
https://www.ncbi.nlm.nih.gov/pubmed/36083902
http://dx.doi.org/10.1126/sciadv.abn4030

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