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Adoption of HIV pre-exposure prophylaxis among women at high risk of HIV infection in Kenya

In 2017, Kenya became one of the first African countries to provide pre-exposure prophylaxis (PrEP) in its national HIV prevention plan. We sought to characterize factors associated with PrEP uptake and persistence among a cohort of women at risk of HIV infection during the early stages of PrEP scal...

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Autores principales: Bien-Gund, Cedric H., Ochwal, Perez, Marcus, Noora, Bair, Elizabeth F., Napierala, Sue, Maman, Suzanne, Agot, Kawango, Thirumurthy, Harsha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462728/
https://www.ncbi.nlm.nih.gov/pubmed/36084050
http://dx.doi.org/10.1371/journal.pone.0273409
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author Bien-Gund, Cedric H.
Ochwal, Perez
Marcus, Noora
Bair, Elizabeth F.
Napierala, Sue
Maman, Suzanne
Agot, Kawango
Thirumurthy, Harsha
author_facet Bien-Gund, Cedric H.
Ochwal, Perez
Marcus, Noora
Bair, Elizabeth F.
Napierala, Sue
Maman, Suzanne
Agot, Kawango
Thirumurthy, Harsha
author_sort Bien-Gund, Cedric H.
collection PubMed
description In 2017, Kenya became one of the first African countries to provide pre-exposure prophylaxis (PrEP) in its national HIV prevention plan. We sought to characterize factors associated with PrEP uptake and persistence among a cohort of women at risk of HIV infection during the early stages of PrEP scale-up in Kenya. HIV-negative women ≥18 years with ≥2 sexual partners in the past 4 weeks were recruited as part of an ongoing cluster randomized trial of an HIV self-testing intervention. PrEP use was assessed at baseline and at 6- and 12-month follow-up visits. Between June 2017 and August 2018, 2,086 were enrolled and had complete baseline data. 138 (6.6%) reported PrEP use during the first year of the study. Although PrEP use increased, persistence on PrEP was low, and less than half of individuals reported continuing PrEP at follow-up visits. In multivariate analyses, PrEP use was associated with recent STIs, having an HIV-positive primary partner, having regular transactional sex in the past 12 months, and being a female sex worker. In the early stages of PrEP scale-up in Kenya, uptake increased modestly among women with risk factors for HIV infection, but overall uptake and persistence was low.
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spelling pubmed-94627282022-09-10 Adoption of HIV pre-exposure prophylaxis among women at high risk of HIV infection in Kenya Bien-Gund, Cedric H. Ochwal, Perez Marcus, Noora Bair, Elizabeth F. Napierala, Sue Maman, Suzanne Agot, Kawango Thirumurthy, Harsha PLoS One Research Article In 2017, Kenya became one of the first African countries to provide pre-exposure prophylaxis (PrEP) in its national HIV prevention plan. We sought to characterize factors associated with PrEP uptake and persistence among a cohort of women at risk of HIV infection during the early stages of PrEP scale-up in Kenya. HIV-negative women ≥18 years with ≥2 sexual partners in the past 4 weeks were recruited as part of an ongoing cluster randomized trial of an HIV self-testing intervention. PrEP use was assessed at baseline and at 6- and 12-month follow-up visits. Between June 2017 and August 2018, 2,086 were enrolled and had complete baseline data. 138 (6.6%) reported PrEP use during the first year of the study. Although PrEP use increased, persistence on PrEP was low, and less than half of individuals reported continuing PrEP at follow-up visits. In multivariate analyses, PrEP use was associated with recent STIs, having an HIV-positive primary partner, having regular transactional sex in the past 12 months, and being a female sex worker. In the early stages of PrEP scale-up in Kenya, uptake increased modestly among women with risk factors for HIV infection, but overall uptake and persistence was low. Public Library of Science 2022-09-09 /pmc/articles/PMC9462728/ /pubmed/36084050 http://dx.doi.org/10.1371/journal.pone.0273409 Text en © 2022 Bien-Gund et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Bien-Gund, Cedric H.
Ochwal, Perez
Marcus, Noora
Bair, Elizabeth F.
Napierala, Sue
Maman, Suzanne
Agot, Kawango
Thirumurthy, Harsha
Adoption of HIV pre-exposure prophylaxis among women at high risk of HIV infection in Kenya
title Adoption of HIV pre-exposure prophylaxis among women at high risk of HIV infection in Kenya
title_full Adoption of HIV pre-exposure prophylaxis among women at high risk of HIV infection in Kenya
title_fullStr Adoption of HIV pre-exposure prophylaxis among women at high risk of HIV infection in Kenya
title_full_unstemmed Adoption of HIV pre-exposure prophylaxis among women at high risk of HIV infection in Kenya
title_short Adoption of HIV pre-exposure prophylaxis among women at high risk of HIV infection in Kenya
title_sort adoption of hiv pre-exposure prophylaxis among women at high risk of hiv infection in kenya
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462728/
https://www.ncbi.nlm.nih.gov/pubmed/36084050
http://dx.doi.org/10.1371/journal.pone.0273409
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